OR2F1

OR2F1
Identifiers
Aliases	OR2F1, OLF3, OR14-60, OR2F3, OR2F3P, OR2F4, OR2F5, OR7-139, OR7-140, 7M1-2, olfactory receptor family 2 subfamily F member 1 (gene/pseudogene), olfactory receptor family 2 subfamily F member 1
External IDs	OMIM: 608497; MGI: 3030287; HomoloGene: 128151; GeneCards: OR2F1; OMA:OR2F1 - orthologs
Gene location (Human) Chr. Chromosome 7 (human) Band 7q35 Start 143,954,844 bp End 143,997,312 bp
Gene location (Mouse) Chr. Chromosome 6 (mouse) Band 6|6 B2.1 Start 42,716,305 bp End 42,723,897 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tibial arteries apex of heart smooth muscle tissue sural nerve placenta anterior cingulate cortex ascending aorta Descending thoracic aorta appendix right coronary artery n/a More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity olfactory receptor activity Cellular component membrane integral component of membrane plasma membrane Biological process response to stimulus signal transduction sensory perception of smell detection of chemical stimulus involved in sensory perception of smell G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 26211 258016 Ensembl ENSG00000284866 ENSG00000213215 ENSMUSG00000095831 UniProt Q13607 Q7TRV7 RefSeq (mRNA) NM_012369 NM_001011799 RefSeq (protein) NP_036501 NP_001011799 Location (UCSC) Chr 7: 143.95 – 144 Mb Chr 6: 42.72 – 42.72 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Olfactory receptor 2F1 is a protein that in humans is encoded by the OR2F1 gene.

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.

See also

• Olfactory receptor

Further reading

• Issel-Tarver L, Rine J (1997). "The evolution of mammalian olfactory receptor genes". Genetics. 145 (1): 185–95. doi:10.1093/genetics/145.1.185. PMC 1207777. PMID 9017400.
• Fuchs T, Malecova B, Linhart C, et al. (2003). "DEFOG: a practical scheme for deciphering families of genes". Genomics. 80 (3): 295–302. doi:10.1006/geno.2002.6830. PMID 12213199.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Volz A, Ehlers A, Younger R, et al. (2003). "Complex transcription and splicing of odorant receptor genes". J. Biol. Chem. 278 (22): 19691–701. doi:10.1074/jbc.M212424200. PMID 12637542.
• Scherer SW, Cheung J, MacDonald JR, et al. (2003). "Human chromosome 7: DNA sequence and biology". Science. 300 (5620): 767–72. Bibcode:2003Sci...300..767S. doi:10.1126/science.1083423. PMC 2882961. PMID 12690205.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proc. Natl. Acad. Sci. U.S.A. 101 (8): 2584–9. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.

External links

• OR2F1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.