OR1B1
| OR1B1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | OR1B1, OR9-26, OR9-B, olfactory receptor family 1 subfamily B member 1 (gene/pseudogene), olfactory receptor family 1 subfamily B member 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | MGI: 3030196; HomoloGene: 17479; GeneCards: OR1B1; OMA:OR1B1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Olfactory receptor 1B1 is a protein that in humans is encoded by the OR1B1 gene.[5] Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[5]
Ligands
[edit]As of 2024, OR1B1 was an orphan receptor, meaning that no odorants have been identified which bind to it.[6][7]
See also
[edit]References
[edit]- 1 2 3 GRCh38: Ensembl release 89: ENSG00000280094 – Ensembl, May 2017
- 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000075377 – Ensembl, May 2017
- ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- 1 2 "Entrez Gene: OR1B1 olfactory receptor, family 1, subfamily B, member 1".
- ↑ de March CA, Ryu S, Sicard G, Moon C, Golebiowski J (September 2015). "Structure–odour relationships reviewed in the postgenomic era". Flavour and Fragrance Journal. 30 (5): 342–361. doi:10.1002/ffj.3249.
- ↑ "OR1B1". M2OR. ChemSenSim lab, Université Côte d’Azur, Institut de Chimie de Nice. 2024-03-23. Retrieved 2024-07-04.
Further reading
[edit]- Malnic B, Godfrey PA, Buck LB (2004). "The human olfactory receptor gene family". Proceedings of the National Academy of Sciences of the United States of America. 101 (8): 2584–2589. Bibcode:2004PNAS..101.2584M. doi:10.1073/pnas.0307882100. PMC 356993. PMID 14983052.
External links
[edit]- OR1B1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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