LGR6

LGR6
Identifiers
Aliases	LGR6, GPCR, VTS20631, leucine-rich repeat containing G protein-coupled receptor 6, leucine rich repeat containing G protein-coupled receptor 6
External IDs	OMIM: 606653; MGI: 2441805; GeneCards: LGR6
Gene location (Human) Chr. Chromosome 1 (human) Band 1q32.1 Start 202,193,799 bp End 202,319,781 bp
Gene location (Mouse) Chr. Chromosome 1 (mouse) Band 1|1 E4 Start 134,911,039 bp End 135,033,014 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right coronary artery Descending thoracic aorta ascending aorta left coronary artery granulocyte cardiac muscle tissue of right atrium gastric mucosa popliteal artery tibial arteries anterior pituitary Top expressed in ascending aorta aortic valve skin of external ear molar secondary oocyte right ventricle median eminence primary oocyte skin of back epidermis More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding G protein-coupled receptor activity transmembrane signaling receptor activity signal transducer activity protein-hormone receptor activity heparin binding Roundabout binding Cellular component integral component of membrane vesicle plasma membrane integral component of plasma membrane trans-Golgi network membrane membrane extracellular space Biological process positive regulation of canonical Wnt signaling pathway positive regulation of Wnt signaling pathway G protein-coupled receptor signaling pathway Wnt signaling pathway signal transduction positive regulation of cell migration tissue regeneration bone regeneration axon guidance negative chemotaxis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 59352 329252 Ensembl ENSG00000133067 ENSMUSG00000042793 UniProt Q9HBX8 Q3UVD5 RefSeq (mRNA) NM_001017403 NM_001017404 NM_021636 NM_001033409 RefSeq (protein) NP_001017403 NP_001017404 NP_067649 NP_001028581 Location (UCSC) Chr 1: 202.19 – 202.32 Mb Chr 1: 134.91 – 135.03 Mb PubMed search
Wikidata
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Leucine-rich repeat-containing G-protein coupled receptor 6 is a protein that in humans is encoded by the LGR6 gene. Along with the other G-protein coupled receptors LGR4 and LGR5, LGR6 is a Wnt signaling pathway mediator. LGR6 also acts as an epithelial stem cell marker in squamous cell carcinoma in mice in vivo.

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants.

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
• Takeda S, Kadowaki S, Haga T, Takaesu H, Mitaku S (June 2002). "Identification of G protein-coupled receptor genes from the human genome sequence". FEBS Letters. 520 (1–3): 97–101. doi:10.1016/S0014-5793(02)02775-8. PMID 12044878. S2CID 7116392.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, et al. (October 2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Research. 13 (10): 2265–2270. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.