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TAS2R42

From Wikipedia, the free encyclopedia

TAS2R42

Identifiers

TAS2R42, T2R24, T2R42, T2R55, TAS2R55, taste 2 receptor member 42

External IDs

OMIM: 613966; MGI: 2681280; HomoloGene: 52298; GeneCards: TAS2R42; OMA:TAS2R42 - orthologs

Gene location (Human)

Chr.	Chromosome 12 (human)^[1]

Band	12p13.2	Start	11,185,993 bp^[1]
Band	12p13.2	End	11,186,937 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 6 (mouse)^[2]

Band	6 G1\|6 64.03 cM	Start	132,933,847 bp^[2]
Band	6 G1\|6 64.03 cM	End	132,934,882 bp^[2]

RNA expression pattern

Human

Mouse (ortholog)

Top expressed in

testicle

tonsil

superior frontal gyrus

ganglionic eminence

renal cortex

myeloid leukocyte

monocyte

duodenum

lymph node

islet of Langerhans

n/a

More reference expression data

n/a

Gene ontology
Molecular function	G protein-coupled receptor activity signal transducer activity bitter taste receptor activity
Cellular component	integral component of membrane plasma membrane membrane
Biological process	detection of chemical stimulus involved in sensory perception of bitter taste signal transduction response to stimulus sensory perception of taste G protein-coupled receptor signaling pathway
Sources:Amigo / QuickGO

Species

Human

Mouse


353164


387356


ENSG00000273505 ENSG00000186136


ENSMUSG00000057699


Q7RTR8


Q7M708

RefSeq (mRNA)


NM_181429


NM_207030

RefSeq (protein)


NP_852094


NP_996913

Location (UCSC)

Chr 12: 11.19 – 11.19 Mb

Chr 6: 132.93 – 132.93 Mb

PubMed search

^[3]

^[4]

View/Edit Human

View/Edit Mouse

Taste receptor, type 2, member 42 is a protein that in humans is encoded by the TAS2R42 gene.^[5]^[6]

References

1 2 3 ENSG00000186136 GRCh38: Ensembl release 89: ENSG00000273505, ENSG00000186136 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000057699 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: taste receptor".
↑ Shi P, Zhang J, Yang H, Zhang YP (May 2003). "Adaptive diversification of bitter taste receptor genes in Mammalian evolution". Mol. Biol. Evol. 20 (5): 805–14. doi:10.1093/molbev/msg083. PMID 12679530.

Further reading

Fischer A, Gilad Y, Man O, Pääbo S (2005). "Evolution of bitter taste receptors in humans and apes". Mol. Biol. Evol. 22 (3): 432–6. doi:10.1093/molbev/msi027. PMID 15496549.
Go Y, Satta Y, Takenaka O, Takahata N (2005). "Lineage-specific loss of function of bitter taste receptor genes in humans and nonhuman primates". Genetics. 170 (1): 313–26. doi:10.1534/genetics.104.037523. PMC 1449719. PMID 15744053.

Cell surface receptor: G protein-coupled receptors

Class A: Rhodopsin-like

Neurotransmitter

Adrenergic	α1 A B D α2 A B C β1 β2 β3
Purinergic	Adenosine A1 A2A A2B A3 P2Y 1 2 4 5 6 8 9 10 11 12 13 14
Serotonin	(all but 5-HT3) 5-HT1 A B D E F 5-HT2 A B C 5-HT 4 5A 6 7
Other	Acetylcholine M1 M2 M3 M4 M5 Dopamine D1 D2 D3 D4 D5 GHB receptor Histamine H1 H2 H3 H4 Melatonin 1A 1B 1C TAAR 1 2 5 6 8 9

Metabolites and
signaling molecules

Eicosanoid	CysLT 1 2 LTB4 1 2 FPRL1 OXE Prostaglandin DP 1 2 EP 1 2 3 4 FP Prostacyclin Thromboxane
Other	Bile acid Cannabinoid CB1 CB2 GPR 18 55 119 EBI2 Estrogen Free fatty acid 1 2 3 4 Hydroxycarboxylic acids 1 2 3 Lysophosphatidic acid 1 2 3 4 5 6 Lysophospholipid 1 2 3 4 5 6 7 8 Oxoglutarate PAF Sphingosine-1-phosphate 1 2 3 4 5 Succinate

Peptide

B/W
- 1
- 2
FF
- 1
- 2
S
Y
- 1
- 2
- 4
- 5
Neuromedin
- B
- U
  - 1
  - 2
Neurotensin
- 1
- 2

Other

Miscellaneous

Taste, bitter	TAS2R 1 3 4 5 7 8 9 10 13 14 16 19 20 30 31 38 39 40 41 42 43 45 46 50 60 Vomeronasal receptor type 1
Orphan	GPR 3 4 6 12 15 17 18 19 20 21 22 26 27 31 32 33 34 35 37 39 42 45 50 52 55 61 62 63 65 68 75 78 82 83 84 85 87 88 101 103 109A 119 132 135 137B 139 141 142 146 148 149 150 151 152 153 160 161 162 171 173 174 176 177 182 183
Other	Adrenomedullin Olfactory Opsin 3 4 5 1LW 1MW 1SW RGR RRH Protease-activated 1 2 3 4 SREB 1 2 3

Class B: Secretin-like

Adhesion	ADGRB Brain-specific angiogenesis inhibitor 1 2 3 ADGRC Cadherin 1 2 3 ADGRE EMR 1 2 3 CD97 ADGRG 1 2 3 4 5 6 7 ADGRL Latrophilin 1 2 3 ELTD1
Orphan	GPR 56 64 97 98 110 111 112 113 114 115 116 123 124 125 126 128 133 143 144 155 157
Other	Calcitonin CALCRL Corticotropin-releasing hormone 1 2 Glucagon GR GIPR GLP1R GLP2R Growth-hormone-releasing hormone PACAPR1 GPR Methuselah-like proteins Parathyroid hormone 1 2 Secretin Vasoactive intestinal peptide 1 2

Class C: Metabotropic glutamate / pheromone

Taste, sweet	TAS1R 1 2 3 Vomeronasal receptor, type 2
Other	Calcium-sensing receptor GABA_B 1 2 Glutamate receptor Metabotropic glutamate 1 2 3 4 5 6 7 8 GPRC6A GPR 156 158 179 RAIG 1 2 3 4

Class F: Frizzled & Smoothened

Frizzled	Frizzled 1 2 3 4 5 6 7 8 9 10
Smoothened	Smoothened
Category Commons

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