// Workers AI · dad joke modeWhat did F2RL3 say to its friend? You're a real factor.

F2RL3
Identifiers
Aliases	F2RL3, PAR4, F2R like thrombin/trypsin receptor 3, F2R like thrombin or trypsin receptor 3
External IDs	OMIM: 602779; MGI: 1298207; HomoloGene: 36148; GeneCards: F2RL3; OMA:F2RL3 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2ZPK, 3QDZ
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.11 Start 16,888,999 bp End 16,892,606 bp
Gene location (Mouse) Chr. Chromosome 8 (mouse) Band 8 35.08 cM|8 B3.3 Start 73,488,508 bp End 73,490,502 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lung upper lobe of left lung left lobe of thyroid gland subcutaneous adipose tissue islet of Langerhans right lobe of thyroid gland lactiferous gland monocyte body of stomach transverse colon Top expressed in left lobe of liver right lobe of liver vasculature vasculature of organ choroid plexus embryo spleen yolk sac quadriceps femoris muscle placenta More reference expression data BioGPS More reference expression data
Gene ontology Molecular function thrombin-activated receptor activity signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane extracellular region integral component of plasma membrane membrane plasma membrane Biological process platelet activation hemostasis phospholipase C-activating G protein-coupled receptor signaling pathway thrombin-activated receptor signaling pathway positive regulation of release of sequestered calcium ion into cytosol platelet dense granule organization response to wounding signal transduction blood coagulation positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 9002 14065 Ensembl ENSG00000127533 ENSMUSG00000050147 UniProt Q96RI0 O88634 RefSeq (mRNA) NM_003950 NM_007975 RefSeq (protein) NP_003941 NP_032001 Location (UCSC) Chr 19: 16.89 – 16.89 Mb Chr 8: 73.49 – 73.49 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Protease-activated receptor 4 (PAR-4), also known as coagulation factor II (thrombin) receptor-like 3, is a protein that in humans is encoded by the F2RL3 gene.

Function

Coagulation factor II (thrombin) receptor-like 3 (F2RL3) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL3 is also a member of the protease-activated receptor family. F2RL3 is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. F2RL3 is activated by thrombin and trypsin.

See also

• Protease-activated receptor

Further reading

• Leger AJ, Covic L, Kuliopulos A (2006). "Protease-activated receptors in cardiovascular diseases". Circulation. 114 (10): 1070–7. doi:10.1161/CIRCULATIONAHA.105.574830. PMID 16952995. S2CID 312800.
• Xu WF, Andersen H, Whitmore TE, et al. (1998). "Cloning and characterization of human protease-activated receptor 4". Proc. Natl. Acad. Sci. U.S.A. 95 (12): 6642–6. Bibcode:1998PNAS...95.6642X. doi:10.1073/pnas.95.12.6642. PMC 22580. PMID 9618465.
• Kahn ML, Zheng YW, Huang W, et al. (1998). "A dual thrombin receptor system for platelet activation". Nature. 394 (6694): 690–4. Bibcode:1998Natur.394..690K. doi:10.1038/29325. PMID 9716134. S2CID 4408582.
• Kahn ML, Hammes SR, Botka C, Coughlin SR (1998). "Gene and locus structure and chromosomal localization of the protease-activated receptor gene family". J. Biol. Chem. 273 (36): 23290–6. doi:10.1074/jbc.273.36.23290. PMID 9722561. S2CID 32777201.
• Kahn ML, Nakanishi-Matsui M, Shapiro MJ, et al. (1999). "Protease-activated receptors 1 and 4 mediate activation of human platelets by thrombin". J. Clin. Invest. 103 (6): 879–87. doi:10.1172/JCI6042. PMC 408153. PMID 10079109.
• Andersen H, Greenberg DL, Fujikawa K, et al. (1999). "Protease-activated receptor 1 is the primary mediator of thrombin-stimulated platelet procoagulant activity". Proc. Natl. Acad. Sci. U.S.A. 96 (20): 11189–93. Bibcode:1999PNAS...9611189A. doi:10.1073/pnas.96.20.11189. PMC 18009. PMID 10500152.
• Sambrano GR, Huang W, Faruqi T, et al. (2000). "Cathepsin G activates protease-activated receptor-4 in human platelets". J. Biol. Chem. 275 (10): 6819–23. doi:10.1074/jbc.275.10.6819. PMID 10702240. S2CID 33219053.
• Nakanishi-Matsui M, Zheng YW, Sulciner DJ, et al. (2000). "PAR3 is a cofactor for PAR4 activation by thrombin". Nature. 404 (6778): 609–13. Bibcode:2000Natur.404..609N. doi:10.1038/35007085. PMID 10766244. S2CID 4410800.
• Miike S, McWilliam AS, Kita H (2002). "Trypsin induces activation and inflammatory mediator release from human eosinophils through protease-activated receptor-2". J. Immunol. 167 (11): 6615–22. doi:10.4049/jimmunol.167.11.6615. PMID 11714832. S2CID 9302877.
• Asokananthan N, Graham PT, Fink J, et al. (2002). "Activation of protease-activated receptor (PAR)-1, PAR-2, and PAR-4 stimulates IL-6, IL-8, and prostaglandin E2 release from human respiratory epithelial cells". J. Immunol. 168 (7): 3577–85. doi:10.4049/jimmunol.168.7.3577. PMID 11907122. S2CID 45171728.
• Henriksen RA, Hanks VK (2002). "PAR-4 agonist AYPGKF stimulates thromboxane production by human platelets". Arterioscler. Thromb. Vasc. Biol. 22 (5): 861–6. doi:10.1161/01.ATV.0000014742.56572.25. PMID 12006403. S2CID 24246544.
• Covic L, Singh C, Smith H, Kuliopulos A (2003). "Role of the PAR4 thrombin receptor in stabilizing platelet-platelet aggregates as revealed by a patient with Hermansky-Pudlak syndrome". Thromb. Haemost. 87 (4): 722–7. doi:10.1055/s-0037-1613071. PMID 12008957. S2CID 32831294.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Owen WG (2003). "PAR-3 is a low-affinity substrate, high affinity effector of thrombin". Biochem. Biophys. Res. Commun. 305 (1): 166–8. Bibcode:2003BBRC..305..166O. doi:10.1016/S0006-291X(03)00732-0. PMID 12732212.
• Adam F, Verbeuren TJ, Fauchère JL, et al. (2003). "Thrombin-induced platelet PAR4 activation: role of glycoprotein Ib and ADP". J. Thromb. Haemost. 1 (4): 798–804. doi:10.1046/j.1538-7836.2003.00138.x. PMID 12871418. S2CID 12762388.
• Wu CC, Hwang TL, Liao CH, et al. (2004). "The role of PAR4 in thrombin-induced thromboxane production in human platelets". Thromb. Haemost. 90 (2): 299–308. doi:10.1160/TH03-02-0103. PMID 12888878. S2CID 4983617.
• Kawai T, Akira S, Reed JC (2003). "ZIP kinase triggers apoptosis from nuclear PML oncogenic domains". Mol. Cell. Biol. 23 (17): 6174–86. doi:10.1128/MCB.23.17.6174-6186.2003. PMC 180930. PMID 12917339.
• Jacques SL, Kuliopulos A (2004). "Protease-activated receptor-4 uses dual prolines and an anionic retention motif for thrombin recognition and cleavage". Biochem. J. 376 (Pt 3): 733–40. doi:10.1042/BJ20030954. PMC 1223816. PMID 13678420.
• Han Y, Nurden A, Combrié R, Pasquet JM (2004). "Redistribution of glycoprotein Ib within platelets in response to protease-activated receptors 1 and 4: roles of cytoskeleton and calcium". J. Thromb. Haemost. 1 (10): 2206–15. doi:10.1046/j.1538-7836.2003.00436.x. PMID 14521606. S2CID 24420859.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.