GPR4

GPR4
Identifiers
Aliases	GPR4, G protein-coupled receptor 4, GPR6C.l
External IDs	OMIM: 600551; MGI: 2441992; GeneCards: GPR4
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.32 Start 45,589,764 bp End 45,602,212 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A3 Start 18,946,463 bp End 18,958,099 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in upper lobe of left lung right lung apex of heart left lobe of thyroid gland right lobe of thyroid gland left ventricle pericardium subcutaneous adipose tissue epithelium of colon tibial nerve Top expressed in molar otolith organ utricle habenula myocardium of ventricle medial dorsal nucleus seminiferous tubule muscle of thigh medial head of gastrocnemius muscle embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signal transducer activity G protein-coupled receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process negative regulation of angiogenesis angiogenesis involved in wound healing G protein-coupled receptor signaling pathway glomerular mesangial cell development signal transduction response to acidic pH positive regulation of Rho protein signal transduction positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 2828 319197 Ensembl ENSG00000177464 ENSMUSG00000044317 UniProt P46093 Q8BUD0 RefSeq (mRNA) NM_005282 NM_175668 RefSeq (protein) NP_005273 NP_783599 Location (UCSC) Chr 19: 45.59 – 45.6 Mb Chr 7: 18.95 – 18.96 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

G-protein coupled receptor 4 is a protein that in humans is encoded by the GPR4 gene.

See also

• Proton-sensing G protein-coupled receptors

Further reading

• An S, Tsai C, Goetzl EJ (1996). "Cloning, sequencing and tissue distribution of two related G protein-coupled receptor candidates expressed prominently in human lung tissue". FEBS Lett. 375 (1–2): 121–4. doi:10.1016/0014-5793(95)01196-L. PMID 7498459. S2CID 9845527.
• Heiber M, Docherty JM, Shah G, Nguyen T, Cheng R, Heng HH, Marchese A, Tsui LC, Shi X (1995). "Isolation of three novel human genes encoding G protein-coupled receptors". DNA Cell Biol. 14 (1): 25–35. doi:10.1089/dna.1995.14.25. PMID 7832990.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Lum H, Qiao J, Walter RJ, Huang F, Subbaiah PV, Kim KS, Holian O (2003). "Inflammatory stress increases receptor for lysophosphatidylcholine in human microvascular endothelial cells". Am. J. Physiol. Heart Circ. Physiol. 285 (4): H1786–9. doi:10.1152/ajpheart.00359.2003. PMID 12805023.
• Ludwig MG, Vanek M, Guerini D, Gasser JA, Jones CE, Junker U, Hofstetter H, Wolf RM, Seuwen K (2003). "Proton-sensing G-protein-coupled receptors". Nature. 425 (6953): 93–8. Bibcode:2003Natur.425...93L. doi:10.1038/nature01905. PMID 12955148. S2CID 4395698.
• Bektas M, Barak LS, Jolly PS, Liu H, Lynch KR, Lacana E, Suhr KB, Milstien S, Spiegel S (2003). "The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner". Biochemistry. 42 (42): 12181–91. doi:10.1021/bi035051y. PMID 14567679.
• Sin WC, Zhang Y, Zhong W, Adhikarakunnathu S, Powers S, Hoey T, An S, Yang J (2004). "G protein-coupled receptors GPR4 and TDAG8 are oncogenic and overexpressed in human cancers". Oncogene. 23 (37): 6299–303. doi:10.1038/sj.onc.1207838. PMID 15221007. S2CID 23448180.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kim KS, Ren J, Jiang Y, Ebrahem Q, Tipps R, Cristina K, Xiao YJ, Qiao J, Taylor KL (2005). "GPR4 plays a critical role in endothelial cell function and mediates the effects of sphingosylphosphorylcholine". FASEB J. 19 (7): 819–21. doi:10.1096/fj.04-2988fje. PMID 15857892. S2CID 23640250.
• Qiao J, Huang F, Naikawadi RP, Kim KS, Said T, Lum H (2006). "Lysophosphatidylcholine impairs endothelial barrier function through the G protein-coupled receptor GPR4". Am. J. Physiol. Lung Cell Mol. Physiol. 291 (1): L91–101. doi:10.1152/ajplung.00508.2005. PMID 16461426. S2CID 25149978.
• Huang F, Mehta D, Predescu S, Kim K, Lum H (2007). "A novel lysophospholipid- and pH-sensitive receptor, GPR4, in brain endothelial cells regulates monocyte transmigration". Endothelium. 14 (1): 25–34. doi:10.1080/10623320601177288. hdl:2027.42/78980. PMID 17364894.
• Zou Y, Kim CH, Chung JH, Kim JY, Chung SW, Kim MK, Im DS, Lee J, Yu BP (2007). "Upregulation of endothelial adhesion molecules by lysophosphatidylcholine. Involvement of G protein-coupled receptor GPR4". FEBS J. 274 (10): 2573–84. doi:10.1111/j.1742-4658.2007.05792.x. PMID 17437524. S2CID 83245004.
• Tobo M, Tomura H, Mogi C, Wang J, Liu J, Komachi M, Damirin A, Kimura T, Murata N (2007). "Previously postulated "ligand-independent" signaling of GPR4 is mediated through proton-sensing mechanisms". Cell. Signal. 19 (8): 1745–53. doi:10.1016/j.cellsig.2007.03.009. PMID 17462861.