GPR78

GPR78
Identifiers
Aliases	GPR78, G protein-coupled receptor 78
External IDs	OMIM: 606921; GeneCards: GPR78
Gene location (Human) Chr. Chromosome 4 (human) Band 4p16.1 Start 8,558,725 bp End 8,619,761 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in left ovary right ovary vagina stromal cell of endometrium ectocervix right uterine tube canal of the cervix skin of hip gallbladder prefrontal cortex n/a More reference expression data BioGPS n/a
Gene ontology Molecular function G protein-coupled receptor activity signal transducer activity protein binding Cellular component integral component of membrane plasma membrane membrane intracellular anatomical structure Biological process G protein-coupled receptor signaling pathway adenylate cyclase-activating G protein-coupled receptor signaling pathway signal transduction Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 27201 n/a Ensembl ENSG00000155269 n/a UniProt Q96P69 n/a RefSeq (mRNA) NM_080819 n/a RefSeq (protein) NP_543009 n/a Location (UCSC) Chr 4: 8.56 – 8.62 Mb n/a PubMed search n/a
Wikidata
View/Edit Human

Not to be confused with GRP78.

Probable G-protein coupled receptor 78 is a protein that in humans is encoded by the GPR78 gene.

G protein-coupled receptors (GPCRs, or GPRs) contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM]

Further reading

• van Laar T, Schouten T, Hoogervorst E, Van Eck M, Van Der Eb AJ, Terleth C (2000). "The novel MMS-inducible gene Mif1/KIAA0025 is a target of the unfolded protein response pathway". FEBS Lett. 469 (1): 123–31. doi:10.1016/S0014-5793(00)01253-9. PMID 10708769. S2CID 6419566.
• Strausberg RL, Feingold EA, Grouse LH, Derge JG, Klausner RD, Collins FS, Wagner L, Shenmen CM, Schuler GD (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309.
• Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Underwood SL, Christoforou A, Thomson PA, Wray NR, Tenesa A, Whittaker J, Adams RA, Le Hellard S, Morris SW (2006). "Association analysis of the chromosome 4p-located G protein-coupled receptor 78 (GPR78) gene in bipolar affective disorder and schizophrenia". Mol. Psychiatry. 11 (4): 384–94. doi:10.1038/sj.mp.4001786. PMID 16389273. S2CID 12678399.