// Workers AI · dad joke modeWhat did GABPB2 say to its friend? "Let's bind together

This article is about the GABPB gene found on chromosome 1 in humans. For the GABPB gene on chromosome 15, see GABPB1.

GABPB2
Identifiers
Aliases	GABPB2, GABPB-2, GA binding protein transcription factor beta subunit 2, GA binding protein transcription factor subunit beta 2
External IDs	MGI: 95612; GeneCards: GABPB2
Gene location (Human) Chr. Chromosome 1 (human) Band 1q21.3 Start 151,070,578 bp End 151,125,542 bp
Gene location (Mouse) Chr. Chromosome 3 (mouse) Band 3 F2.1|3 40.74 cM Start 95,089,077 bp End 95,125,227 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum thymus tibialis anterior muscle Achilles tendon tibia skin of arm pancreatic ductal cell cardiac muscle tissue of right atrium epithelium of nasopharynx sural nerve Top expressed in hand otolith organ utricle lymph node mesenteric lymph nodes spleen thymus vestibular membrane of cochlear duct condyle conjunctival fornix More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding protein homodimerization activity protein heterodimerization activity DNA-binding transcription factor activity Cellular component nucleus Biological process regulation of transcription, DNA-templated transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 126626 213054 Ensembl ENSG00000143458 ENSMUSG00000038766 UniProt Q8TAK5 P81069 RefSeq (mRNA) NM_144618 NM_001323906 NM_001323907 NM_001323908 NM_001323909 NM_001323910 NM_001323911 NM_001323912 NM_001323913 NM_029885 NM_172512 RefSeq (protein) NP_001310835 NP_001310836 NP_001310837 NP_001310838 NP_001310839 NP_001310840 NP_001310841 NP_001310842 NP_653219 NP_084161 NP_766100 Location (UCSC) Chr 1: 151.07 – 151.13 Mb Chr 3: 95.09 – 95.13 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

GA-binding protein subunit beta-2 is a protein that in humans is encoded by the GABPB2 gene. Not much has been reported about the function of this protein, but it may act as a transcription factor that binds to GA repeats. One of the two primary isoforms of this gene's paralog, GABPB1, was originally named "GABPB2", leading to a name conflict, but the naming conventions were eventually clarified in August 2008.

Further reading

• Sawada J, Goto M, Watanabe H, et al. (1995). "Regional mapping of two subunits of transcription factor E4TF1 to human chromosome". Jpn. J. Cancer Res. 86 (1): 10–2. doi:10.1111/j.1349-7006.1995.tb02981.x. PMC 5920589. PMID 7737900.
• Gugneja S, Virbasius JV, Scarpulla RC (1995). "Four structurally distinct, non-DNA-binding subunits of human nuclear respiratory factor 2 share a conserved transcriptional activation domain". Mol. Cell. Biol. 15 (1): 102–11. doi:10.1128/MCB.15.1.102. PMC 231915. PMID 7799916.
• Virbasius JV, Virbasius CA, Scarpulla RC (1993). "Identity of GABP with NRF-2, a multisubunit activator of cytochrome oxidase expression, reveals a cellular role for an ETS domain activator of viral promoters". Genes Dev. 7 (3): 380–92. doi:10.1101/gad.7.3.380. PMID 8383622.
• Watanabe H, Sawada J, Yano K, et al. (1993). "cDNA cloning of transcription factor E4TF1 subunits with Ets and notch motifs". Mol. Cell. Biol. 13 (3): 1385–91. doi:10.1128/MCB.13.3.1385. PMC 359448. PMID 8441384.
• Gugneja S, Virbasius CM, Scarpulla RC (1996). "Nuclear respiratory factors 1 and 2 utilize similar glutamine-containing clusters of hydrophobic residues to activate transcription". Mol. Cell. Biol. 16 (10): 5708–16. doi:10.1128/mcb.16.10.5708. PMC 231571. PMID 8816484.
• Sawa C, Goto M, Suzuki F, et al. (1997). "Functional domains of transcription factor hGABP beta1/E4TF1-53 required for nuclear localization and transcription activation". Nucleic Acids Res. 24 (24): 4954–61. doi:10.1093/nar/24.24.4954. PMC 146336. PMID 9016666.
• Sowa Y, Shiio Y, Fujita T, et al. (1997). "Retinoblastoma binding factor 1 site in the core promoter region of the human RB gene is activated by hGABP/E4TF1". Cancer Res. 57 (15): 3145–8. PMID 9242441.
• Batchelor AH, Piper DE, de la Brousse FC, et al. (1998). "The structure of GABPalpha/beta: an ETS domain- ankyrin repeat heterodimer bound to DNA". Science. 279 (5353): 1037–41. Bibcode:1998Sci...279.1037B. doi:10.1126/science.279.5353.1037. PMID 9461436.
• Suzuki F, Goto M, Sawa C, et al. (1998). "Functional interactions of transcription factor human GA-binding protein subunits". J. Biol. Chem. 273 (45): 29302–8. doi:10.1074/jbc.273.45.29302. PMID 9792629.
• Sawada J, Simizu N, Suzuki F, et al. (2000). "Synergistic transcriptional activation by hGABP and select members of the activation transcription factor/cAMP response element-binding protein family". J. Biol. Chem. 274 (50): 35475–82. doi:10.1074/jbc.274.50.35475. PMID 10585419.
• Vogel JL, Kristie TM (2000). "The novel coactivator C1 (HCF) coordinates multiprotein enhancer formation and mediates transcription activation by GABP". EMBO J. 19 (4): 683–90. doi:10.1093/emboj/19.4.683. PMC 305606. PMID 10675337.
• Sawa C, Yoshikawa T, Matsuda-Suzuki F, et al. (2002). "YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors". J. Biol. Chem. 277 (25): 22484–90. doi:10.1074/jbc.M203060200. PMID 11953439.
• Marie S, Race V, Nassogne MC, et al. (2002). "Mutation of a nuclear respiratory factor 2 binding site in the 5' untranslated region of the ADSL gene in three patients with adenylosuccinate lyase deficiency". Am. J. Hum. Genet. 71 (1): 14–21. doi:10.1086/341036. PMC 384970. PMID 12016589.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID 16189514. S2CID 4427026.
• Jeong BC, Kim MY, Lee JH, et al. (2006). "Brain-specific angiogenesis inhibitor 2 regulates VEGF through GABP that acts as a transcriptional repressor". FEBS Lett. 580 (2): 669–76. Bibcode:2006FEBSL.580..669J. doi:10.1016/j.febslet.2005.12.086. PMID 16412436. S2CID 35468847.
• Lim J, Hao T, Shaw C, et al. (2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. 125 (4): 801–14. doi:10.1016/j.cell.2006.03.032. PMID 16713569. S2CID 13709685.

External links

• GABPB2+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)