TCF7

For the TCF1 gene, see HNF1A.

TCF7
Identifiers
Aliases	TCF7, TCF-1, transcription factor 7 (T-cell specific, HMG-box), transcription factor 7
External IDs	OMIM: 189908; MGI: 98507; GeneCards: TCF7
Gene location (Human) Chr. Chromosome 5 (human) Band 5q31.1 Start 134,114,681 bp End 134,151,865 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.3|11 31.86 cM Start 52,252,371 bp End 52,283,014 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in thymus periodontal fiber lymph node right uterine tube granulocyte cecum appendix blood cardia buccal mucosa cell Top expressed in thymus mesenteric lymph nodes tail of embryo zygote blood labioscrotal swelling secondary oocyte molar epiblast spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity protein binding DNA-binding transcription repressor activity, RNA polymerase II-specific beta-catenin binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus nucleoplasm nuclear body Biological process cellular response to interleukin-4 regulation of transcription, DNA-templated T cell receptor V(D)J recombination negative regulation of transcription by RNA polymerase II embryonic hindgut morphogenesis Wnt signaling pathway transcription, DNA-templated canonical Wnt signaling pathway involved in negative regulation of apoptotic process embryonic genitalia morphogenesis regulation of cell population proliferation immune response neural tube development embryonic digestive tract morphogenesis alpha-beta T cell differentiation beta-catenin-TCF complex assembly regulation of transcription by RNA polymerase II canonical Wnt signaling pathway Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 6932 21414 Ensembl ENSG00000081059 ENSMUSG00000000782 UniProt P36402 Q00417 RefSeq (mRNA) NM_001134851 NM_001134852 NM_003202 NM_201632 NM_201634 NM_213648 NM_001346425 NM_001346450 NM_001366502 NM_009331 NM_001313981 RefSeq (protein) NP_001128323 NP_001333354 NP_001333379 NP_003193 NP_963963 NP_963965 NP_998813 NP_001353431 NP_001300910 NP_033357 Location (UCSC) Chr 5: 134.11 – 134.15 Mb Chr 11: 52.25 – 52.28 Mb PubMed search
Wikidata
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Transcription factor 7 is the gene that in humans encodes for the TCF1 protein.

Further reading

• van de Wetering M, Oosterwegel M, Holstege F, et al. (1992). "The human T cell transcription factor-1 gene. Structure, localization, and promoter characterization". J. Biol. Chem. 267 (12): 8530–6. doi:10.1016/S0021-9258(18)42476-3. PMID 1569101.
• van de Wetering M, Oosterwegel M, Dooijes D, Clevers H (1991). "Identification and cloning of TCF-1, a T lymphocyte-specific transcription factor containing a sequence-specific HMG box". EMBO J. 10 (1): 123–32. doi:10.1002/j.1460-2075.1991.tb07928.x. PMC 452620. PMID 1989880.
• Castrop J, van Wichen D, Koomans-Bitter M, et al. (1995). "The human TCF-1 gene encodes a nuclear DNA-binding protein uniquely expressed in normal and neoplastic T-lineage lymphocytes". Blood. 86 (8): 3050–9. doi:10.1182/blood.V86.8.3050.3050. hdl:20.500.11755/05a0e0d7-f80c-4035-a8da-056c8b5b7883. PMID 7579399.
• Mayer K, Wolff E, Clevers H, Ballhausen WG (1995). "The human high mobility group (HMG)-box transcription factor TCF-1: novel isoforms due to alternative splicing and usage of a new exon IXA". Biochim. Biophys. Acta. 1263 (2): 169–72. doi:10.1016/0167-4781(95)00108-s. PMID 7640309.
• Van de Wetering M, Castrop J, Korinek V, Clevers H (1996). "Extensive alternative splicing and dual promoter usage generate Tcf-1 protein isoforms with differential transcription control properties". Mol. Cell. Biol. 16 (3): 745–52. doi:10.1128/mcb.16.3.745. PMC 231054. PMID 8622675.
• Korinek V, Barker N, Willert K, et al. (1998). "Two members of the Tcf family implicated in Wnt/beta-catenin signaling during embryogenesis in the mouse". Mol. Cell. Biol. 18 (3): 1248–56. doi:10.1128/MCB.18.3.1248. PMC 108837. PMID 9488439.
• Roose J, Molenaar M, Peterson J, et al. (1998). "The Xenopus Wnt effector XTcf-3 interacts with Groucho-related transcriptional repressors". Nature. 395 (6702): 608–12. Bibcode:1998Natur.395..608R. doi:10.1038/26989. PMID 9783587. S2CID 4347003.
• Roose J, Huls G, van Beest M, et al. (1999). "Synergy between tumor suppressor APC and the beta-catenin-Tcf4 target Tcf1". Science. 285 (5435): 1923–6. doi:10.1126/science.285.5435.1923. PMID 10489374.
• Brantjes H, Roose J, van De Wetering M, Clevers H (2001). "All Tcf HMG box transcription factors interact with Groucho-related co-repressors". Nucleic Acids Res. 29 (7): 1410–9. doi:10.1093/nar/29.7.1410. PMC 31284. PMID 11266540.
• Batlle E, Henderson JT, Beghtel H, et al. (2002). "Beta-catenin and TCF mediate cell positioning in the intestinal epithelium by controlling the expression of EphB/ephrinB". Cell. 111 (2): 251–63. doi:10.1016/S0092-8674(02)01015-2. hdl:20.500.11755/049536a5-2cae-41f6-a443-9ac675ffc736. PMID 12408869. S2CID 10103038.
• Noble JA, White AM, Lazzeroni LC, et al. (2003). "A polymorphism in the TCF7 gene, C883A, is associated with type 1 diabetes". Diabetes. 52 (6): 1579–82. doi:10.2337/diabetes.52.6.1579. PMID 12765974.
• Ioannidis V, Kunz B, Tanamachi DM, et al. (2003). "Initiation and limitation of Ly-49A NK cell receptor acquisition by T cell factor-1". J. Immunol. 171 (2): 769–75. doi:10.4049/jimmunol.171.2.769. PMID 12847244.
• Smit L, Baas A, Kuipers J, et al. (2004). "Wnt activates the Tak1/Nemo-like kinase pathway". J. Biol. Chem. 279 (17): 17232–40. doi:10.1074/jbc.M307801200. PMID 14960582.
• Smith SS, Patterson T, Pauza ME (2005). "Transgenic Ly-49A inhibits antigen-driven T cell activation and delays diabetes". J. Immunol. 174 (7): 3897–905. doi:10.4049/jimmunol.174.7.3897. PMID 15778344.
• Willinger T, Freeman T, Herbert M, et al. (2006). "Human naive CD8 T cells down-regulate expression of the WNT pathway transcription factors lymphoid enhancer binding factor 1 and transcription factor 7 (T cell factor-1) following antigen encounter in vitro and in vivo". J. Immunol. 176 (3): 1439–46. doi:10.4049/jimmunol.176.3.1439. hdl:20.500.11820/b4e3a221-e38b-4f3a-9dbe-1641533de25a. PMID 16424171.