PROP1

PROP1
Identifiers
Aliases	PROP1, CPHD2, PROP-1, PROP paired-like homeobox 1
External IDs	OMIM: 601538; MGI: 109330; HomoloGene: 4558; GeneCards: PROP1; OMA:PROP1 - orthologs
Gene location (Human) Chr. Chromosome 5 (human) Band 5q35.3 Start 177,992,235 bp End 177,996,242 bp
Gene location (Mouse) Chr. Chromosome 11 (mouse) Band 11 B1.3|11 30.95 cM Start 50,841,633 bp End 50,844,592 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pituitary gland anterior pituitary Top expressed in anterior pituitary Rathke's pouch embryo pars distalis of adenohypophysis blastocyst lumbar spinal ganglion digastric muscle lumbar subsegment of spinal cord carotid body spleen More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA binding sequence-specific DNA binding beta-catenin binding chromatin binding DNA-binding transcription repressor activity, RNA polymerase II-specific protein C-terminus binding DNA-binding transcription activator activity, RNA polymerase II-specific protein binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component transcription regulator complex nucleus Biological process regulation of transcription, DNA-templated somatotropin secreting cell differentiation hypothalamus cell differentiation hypophysis morphogenesis negative regulation of apoptotic process negative regulation of transcription by RNA polymerase II transcription by RNA polymerase II adenohypophysis development central nervous system development blood vessel development animal organ morphogenesis canonical Wnt signaling pathway dorsal/ventral pattern formation cell migration positive regulation of transcription by RNA polymerase II gland development Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 5626 19127 Ensembl ENSG00000280635 ENSG00000175325 ENSG00000274382 ENSMUSG00000044542 UniProt O75360 P97458 RefSeq (mRNA) NM_006261 NM_008936 RefSeq (protein) NP_006252 NP_032962 Location (UCSC) Chr 5: 177.99 – 178 Mb Chr 11: 50.84 – 50.84 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Homeobox protein prophet of PIT-1 is a protein that in humans is encoded by the PROP1 gene.

PROP1 has both DNA-binding and transcriptional activation ability. Its expression leads to ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes, and caudomedial thyrotropes. Inactivating mutations in PROP1 result in deficiencies of luteinizing hormone (LH; MIM 152780), follicle-stimulating hormone (FSH; MIM 136530), growth hormone (GH; MIM 139250), prolactin (PRL; MIM 176760), and thyroid-stimulating hormone (TSH; MIM 188540). See combined pituitary hormone deficiency (CPHD; MIM 262600).[supplied by OMIM]

Further reading

• Osorio MG, Kopp P, Marui S, et al. (2000). "Combined pituitary hormone deficiency caused by a novel mutation of a highly conserved residue (F88S) in the homeodomain of PROP-1". J. Clin. Endocrinol. Metab. 85 (8): 2779–85. doi:10.1210/jcem.85.8.6744. PMID 10946881.
• Dasen JS, Rosenfeld MG (2001). "Signaling and transcriptional mechanisms in pituitary development". Annu. Rev. Neurosci. 24 (1): 327–55. doi:10.1146/annurev.neuro.24.1.327. PMID 11283314. S2CID 19902876.
• Mody S, Brown MR, Parks JS (2003). "The spectrum of hypopituitarism caused by PROP1 mutations". Best Pract. Res. Clin. Endocrinol. Metab. 16 (3): 421–31. doi:10.1053/beem.2002.0218. PMID 12464226.
• Rodriguez R, Andersen B (2003). "Cellular determination in the anterior pituitary gland: PIT-1 and PROP-1 mutations as causes of human combined pituitary hormone deficiency". Minerva Endocrinol. 28 (2): 123–33. PMID 12717343.
• Fofanova O, Takamura N, Kinoshita E, et al. (1998). "Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency". J. Clin. Endocrinol. Metab. 83 (7): 2601–4. doi:10.1210/jcem.83.7.5094. PMID 9661653.
• Amendt BA, Sutherland LB, Semina EV, Russo AF (1998). "The molecular basis of Rieger syndrome. Analysis of Pitx2 homeodomain protein activities". J. Biol. Chem. 273 (32): 20066–72. doi:10.1074/jbc.273.32.20066. PMID 9685346.
• Cogan JD, Wu W, Phillips JA, et al. (1998). "The PROP1 2-base pair deletion is a common cause of combined pituitary hormone deficiency" (PDF). J. Clin. Endocrinol. Metab. 83 (9): 3346–9. doi:10.1210/jcem.83.9.5142. hdl:10400.17/2282. PMID 9745452.
• Flück C, Deladoey J, Rutishauser K, et al. (1998). "Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg→Cys at codon 120 (R120C)". J. Clin. Endocrinol. Metab. 83 (10): 3727–34. doi:10.1210/jcem.83.10.5172. PMID 9768691. S2CID 10386868.
• Duquesnoy P, Roy A, Dastot F, et al. (1998). "Human Prop-1: cloning, mapping, genomic structure. Mutations in familial combined pituitary hormone deficiency". FEBS Lett. 437 (3): 216–20. doi:10.1016/S0014-5793(98)01234-4. PMID 9824293. S2CID 20169741.
• Rosenbloom AL, Almonte AS, Brown MR, et al. (1999). "Clinical and biochemical phenotype of familial anterior hypopituitarism from mutation of the PROP1 gene". J. Clin. Endocrinol. Metab. 84 (1): 50–7. doi:10.1210/jcem.84.1.5366. PMID 9920061. S2CID 35502053.
• Mendonca BB, Osorio MG, Latronico AC, et al. (1999). "Longitudinal hormonal and pituitary imaging changes in two females with combined pituitary hormone deficiency due to deletion of A301,G302 in the PROP1 gene". J. Clin. Endocrinol. Metab. 84 (3): 942–5. doi:10.1210/jcem.84.3.5537. PMID 10084575. S2CID 22748592.
• Nakamura Y, Usui T, Mizuta H, et al. (1999). "Characterization of Prophet of Pit-1 gene expression in normal pituitary and pituitary adenomas in humans". J. Clin. Endocrinol. Metab. 84 (4): 1414–9. doi:10.1210/jcem.84.4.5630. PMID 10199788.
• Deladoëy J, Flück C, Büyükgebiz A, et al. (1999). ""Hot spot" in the PROP1 gene responsible for combined pituitary hormone deficiency". J. Clin. Endocrinol. Metab. 84 (5): 1645–50. doi:10.1210/jcem.84.5.5681. PMID 10323394. S2CID 2891639.
• Agarwal G, Bhatia V, Cook S, Thomas PQ (2001). "Adrenocorticotropin deficiency in combined pituitary hormone deficiency patients homozygous for a novel PROP1 deletion". J. Clin. Endocrinol. Metab. 85 (12): 4556–61. doi:10.1210/jcem.85.12.7013. PMID 11134108.
• Vallette-Kasic S, Barlier A, Teinturier C, et al. (2001). "PROP1 gene screening in patients with multiple pituitary hormone deficiency reveals two sites of hypermutability and a high incidence of corticotroph deficiency". J. Clin. Endocrinol. Metab. 86 (9): 4529–35. doi:10.1210/jcem.86.9.7811. PMID 11549703.
• Teinturier C, Vallette S, Adamsbaum C, et al. (2002). "Pseudotumor of the pituitary due to PROP-1 deletion". J. Pediatr. Endocrinol. Metab. 15 (1): 95–101. doi:10.1515/jpem.2002.15.1.95. PMID 11822586. S2CID 9184549.
• Crone J, Pfäffle R, Stobbe H, et al. (2002). "Familial combined pituitary hormone deficiency caused by PROP-1 gene mutation. Growth patterns and MRI studies in untreated subjects". Horm. Res. 57 (3–4): 120–6. doi:10.1159/000057962. PMID 12006708. S2CID 8619602.

External links

• GeneReviews/NCBI/NIH/UW entry on PROP1- Related Combined Pituitary Hormone Deficiency (CPHD)
• PROP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.