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PHF10
Identifiers
Aliases	PHF10, BAF45A, XAP135, PHD finger protein 10, SMARCG4
External IDs	OMIM: 613069; MGI: 1919307; HomoloGene: 10112; GeneCards: PHF10; OMA:PHF10 - orthologs
Gene location (Human) Chr. Chromosome 6 (human) Band 6q27 Start 169,703,902 bp End 169,725,566 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17|17 A2 Start 15,165,271 bp End 15,181,535 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ventricular zone left ovary right adrenal cortex right ovary left adrenal cortex C1 segment Skeletal muscle tissue of rectus abdominis gastric mucosa right lung body of pancreas Top expressed in fetal liver hematopoietic progenitor cell calvaria tail of embryo spermatocyte seminiferous tubule abdominal wall vas deferens human fetus ventricular zone primitive streak More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding metal ion binding histone acetyltransferase activity histone binding Cellular component nucleus npBAF complex histone acetyltransferase complex Biological process regulation of transcription, DNA-templated transcription, DNA-templated nervous system development histone acetylation negative regulation of transcription, DNA-templated positive regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55274 72057 Ensembl ENSG00000130024 ENSMUSG00000023883 UniProt Q8WUB8 Q9D8M7 RefSeq (mRNA) NM_133325 NM_018288 NM_024250 NM_001360983 RefSeq (protein) NP_060758 NP_579866 NP_077212 NP_001347912 Location (UCSC) Chr 6: 169.7 – 169.73 Mb Chr 17: 15.17 – 15.18 Mb PubMed search
Wikidata
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PHD finger protein 10 is a protein that in humans is encoded by the PHF10 gene.

Function

This gene contains a predicted ORF that encodes a protein with two zinc finger domains. The function of the encoded protein is not known. Sequence analysis suggests that multiple alternatively spliced transcript variants are derived from this gene but the full-length nature of only two of them is known. These two splice variants encode different isoforms. A pseudogene for this gene is located on Xq28.

Further reading

• Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (April 1996). "A "double adaptor" method for improved shotgun library construction". Analytical Biochemistry. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID 8619474.
• Rogner UC, Heiss NS, Kioschis P, Wiemann S, Korn B, Poustka A (October 1996). "Transcriptional analysis of the candidate region for incontinentia pigmenti (IP2) in Xq28". Genome Research. 6 (10): 922–34. doi:10.1101/gr.6.10.922. PMID 8908511.
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA (April 1997). "Large-scale concatenation cDNA sequencing". Genome Research. 7 (4): 353–8. doi:10.1101/gr.7.4.353. PMC 139146. PMID 9110174.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP (August 2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins". Proceedings of the National Academy of Sciences of the United States of America. 101 (33): 12130–5. Bibcode:2004PNAS..10112130B. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935.
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.

External links

• PHF10+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.