// Workers AI · dad joke modeWhat did ATF6B say to ATF6A? You're a binding mate.

ATF6B
Identifiers
Aliases	ATF6B, CREB-RP, CREBL1, G13, activating transcription factor 6 beta
External IDs	OMIM: 600984; MGI: 105121; GeneCards: ATF6B
Gene location (Human) Chr. Chromosome 6 (human) Band 6p21.32 Start 32,115,264 bp End 32,128,253 bp
Gene location (Mouse) Chr. Chromosome 17 (mouse) Band 17 B1|17 18.22 cM Start 34,866,120 bp End 34,874,048 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte granulocyte right uterine tube left ovary right ovary right lobe of thyroid gland spleen right hemisphere of cerebellum left lobe of thyroid gland gallbladder Top expressed in yolk sac granulocyte lip dentate gyrus of hippocampal formation granule cell neural layer of retina neural tube ventricular zone thymus choroid plexus of fourth ventricle entorhinal cortex More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA binding DNA-binding transcription factor activity protein binding cAMP response element binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component integral component of membrane Golgi apparatus endoplasmic reticulum membrane membrane intracellular anatomical structure integral component of endoplasmic reticulum membrane protein-DNA complex endoplasmic reticulum nucleus endomembrane system nucleolus RNA polymerase II transcription regulator complex Biological process regulation of transcription, DNA-templated positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress regulation of transcription by RNA polymerase II transcription, DNA-templated endoplasmic reticulum unfolded protein response ATF6-mediated unfolded protein response response to unfolded protein signal transduction transcription by RNA polymerase II positive regulation of transcription by RNA polymerase II negative regulation of ATF6-mediated unfolded protein response Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 1388 12915 Ensembl ENSG00000213676 ENSG00000228628 ENSG00000234539 ENSG00000168468 ENSMUSG00000015461 UniProt Q99941 O35451 RefSeq (mRNA) NM_004381 NM_001136153 NM_017406 RefSeq (protein) NP_001129625 NP_004372 n/a Location (UCSC) Chr 6: 32.12 – 32.13 Mb Chr 17: 34.87 – 34.87 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Cyclic AMP-dependent transcription factor ATF-6 beta is a protein which in humans is encoded by the ATF6B gene (previously CREBL1).

Function

The protein encoded by this gene bears sequence similarity with the Creb/ATF subfamily of the bZip superfamily of transcription factors. It localizes to both the cytoplasm and the nucleus. The gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6.

Further reading

• Bristow J, Tee MK, Gitelman SE, et al. (1993). "Tenascin-X: a novel extracellular matrix protein encoded by the human XB gene overlapping P450c21B". J. Cell Biol. 122 (1): 265–78. doi:10.1083/jcb.122.1.265. PMC 2119596. PMID 7686164.
• Min J, Shukla H, Kozono H, et al. (1996). "A novel Creb family gene telomeric of HLA-DRA in the HLA complex". Genomics. 30 (2): 149–56. doi:10.1006/geno.1995.9891. PMID 8586413.
• Khanna A, Campbell RD (1996). "The gene G13 in the class III region of the human MHC encodes a potential DNA-binding protein". Biochem. J. 319. ( Pt 1) (Pt 1): 81–9. doi:10.1042/bj3190081. PMC 1217738. PMID 8870652.
• Speek M, Barry F, Miller WL (1997). "Alternate promoters and alternate splicing of human tenascin-X, a gene with 5' and 3' ends buried in other genes". Hum. Mol. Genet. 5 (11): 1749–58. doi:10.1093/hmg/5.11.1749. PMID 8923003.
• Swanson DJ, Adachi M, Lewis EJ (2000). "The homeodomain protein Arix promotes protein kinase A-dependent activation of the dopamine beta-hydroxylase promoter through multiple elements and interaction with the coactivator cAMP-response element-binding protein-binding protein". J. Biol. Chem. 275 (4): 2911–23. doi:10.1074/jbc.275.4.2911. PMID 10644760.
• Yoshida H, Okada T, Haze K, et al. (2001). "Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response". Mol. Cell. Biol. 21 (4): 1239–48. doi:10.1128/MCB.21.4.1239-1248.2001. PMC 99577. PMID 11158310.
• Ye J, Rawson RB, Komuro R, et al. (2001). "ER stress induces cleavage of membrane-bound ATF6 by the same proteases that process SREBPs". Mol. Cell. 6 (6): 1355–64. doi:10.1016/S1097-2765(00)00133-7. PMID 11163209.
• Haze K, Okada T, Yoshida H, et al. (2001). "Identification of the G13 (cAMP-response-element-binding protein-related protein) gene product related to activating transcription factor 6 as a transcriptional activator of the mammalian unfolded protein response". Biochem. J. 355 (Pt 1): 19–28. doi:10.1042/0264-6021:3550019. PMC 1221707. PMID 11256944.
• Tong WY, Nagano-Fujii M, Hidajat R, et al. (2003). "Physical interaction between hepatitis C virus NS4B protein and CREB-RP/ATF6beta" (PDF). Biochem. Biophys. Res. Commun. 299 (3): 366–72. doi:10.1016/S0006-291X(02)02638-4. PMID 12445808. Archived from the original (PDF) on 2020-07-12. Retrieved 2020-09-05.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Okada T, Haze K, Nadanaka S, et al. (2003). "A serine protease inhibitor prevents endoplasmic reticulum stress-induced cleavage but not transport of the membrane-bound transcription factor ATF6". J. Biol. Chem. 278 (33): 31024–32. doi:10.1074/jbc.M300923200. PMID 12782636.
• Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
• Xie T, Rowen L, Aguado B, et al. (2004). "Analysis of the gene-dense major histocompatibility complex class III region and its comparison to mouse". Genome Res. 13 (12): 2621–36. doi:10.1101/gr.1736803. PMC 403804. PMID 14656967.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.

External links

• CREBL1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• Human ATF6B genome location and ATF6B gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.