Suloctidil

Suloctidil
Clinical data
ATC code	C04AX19 (WHO) ;
Identifiers
	IUPAC name 1-[4-(isopropylthio)phenyl]-2-(octylamino)propan-1-ol;
CAS Number	54767-75-8 ;
PubChem CID	5354;
ChemSpider	571402;
UNII	XV1N1XY17K;
ChEBI	CHEBI:233445;
ChEMBL	ChEMBL588119;
CompTox Dashboard (EPA)	DTXSID701017974 DTXSID4045638, DTXSID701017974 ;
ECHA InfoCard	100.053.920
Chemical and physical data
Formula	C20H35NOS
Molar mass	337.57 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CCCCCCCCNC(C)C(C1=CC=C(C=C1)SC(C)C)O;
	InChI InChI=1S/C20H35NOS/c1-5-6-7-8-9-10-15-21-17(4)20(22)18-11-13-19(14-12-18)23-16(2)3/h11-14,16-17,20-22H,5-10,15H2,1-4H3; Key:BFCDFTHTSVTWOG-UHFFFAOYSA-N;
	(verify)

Suloctidil was a sulfur-containing aminoalcohol that was brought to market in the early 1970s as a vasodilator by Continental Pharma, a Belgian company.^[1]^{: 118–121}^[2]^[3]

Continental was bought by Monsanto in 1984, primarily on the promise of sales of suloctidil, which was approved in Europe at the time, but not in the US.^[4] However, in 1985 Monsanto halted development and withdrew the drug worldwide following reports of liver toxicity.^[5]^: 251

References

↑ Hladovec J (1989). Antithrombotic Drugs in Thrombosis Models. CRC Press. ISBN 978-0-8493-5162-4.
↑ Roncucci R, Roba J, Lambelin G, Ferenczi M, Blaton V, Vandamme D, Peeters H (March 1975). "Potential antilipolytic activity of suloctidil". Die Naturwissenschaften. 62 (3): 141–2. Bibcode:1975NW.....62..141R. doi:10.1007/bf00623284. PMID 1240601. S2CID 29484315.
↑ BE granted 739678, Buu-Hoi NP, Lambelin G, Roba J, Jacques G, Gillet C, "1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents"
↑ "Monsanto's $150 mil. Life Sciences Research Center". Pharma & Medteck Business Intelligence. 5 November 1984. Archived from the original on 2015-07-07.
↑ "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals" (PDF). Department of Economic and Social Affairs of the United Nations Secretariat. New York: United Nations. 2005.

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[1] Hladovec J (1989). Antithrombotic Drugs in Thrombosis Models. CRC Press. ISBN 978-0-8493-5162-4.

[pmid1240601-2] Roncucci R, Roba J, Lambelin G, Ferenczi M, Blaton V, Vandamme D, Peeters H (March 1975). "Potential antilipolytic activity of suloctidil". Die Naturwissenschaften. 62 (3): 141–2. Bibcode:1975NW.....62..141R. doi:10.1007/bf00623284. PMID 1240601. S2CID 29484315.

[3] BE granted 739678, Buu-Hoi NP, Lambelin G, Roba J, Jacques G, Gillet C, "1-Subst-phenyl-2-amino-ethanols useful as beta adrenergic agents peripheral vasodilators and hypotensive agents"

[4] "Monsanto's $150 mil. Life Sciences Research Center". Pharma & Medteck Business Intelligence. 5 November 1984. Archived from the original on 2015-07-07.

[5] "Consolidated List of Products Whose Consumption and/or Sale Have Been Banned, Withdrawn, Severely Restricted or not Approved by Governments Twelfth Issue: Pharmaceuticals" (PDF). Department of Economic and Social Affairs of the United Nations Secretariat. New York: United Nations. 2005.

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v t e Peripheral vasodilators (C04)
Phenylethanolamine derivatives	Isoxsuprine Buphenine Bamethan
Alpha blockers	Non-selective Buflomedil Phentolamine Phenoxybenzamine Tolazoline Selective α₁-blockers Alfuzosin Doxazosin Prazosin Silodosin Tamsulosin Terazosin
Nicotinic acid and derivatives	Nicotinic acid Nicotinyl alcohol Inositol nicotinate Ciclonicate
Purine derivatives	Pentifylline Xantinol nicotinate Pentoxifylline Etofylline nicotinate
Ergot alkaloids	Ergoloid Nicergoline Dihydroergocristine
Other peripheral vasodilators	Cyclandelate Vincamine Moxisylyte Bencyclane Vinburnine Sulcotidil Naftidrofuryl Butalamine Visnadine Cetiedil Cinepazide Ifenprodil Azapetine Fasudil

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References