Butalamine
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| ECHA InfoCard | 100.040.708 |
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| Formula | C18H28N4O |
| Molar mass | 316.449 g·mol−1 |
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Butalamine is a vasodilator.[1]
Synthesis
[edit]The reaction of benzamidoxime (1) with chlorine and subsequent reaction with cyanamide (3) gives 5-amino-3-phenyl-1,2,4-oxadiazole (4).[2][3][4] Base catalyzed alkylation with dibutylaminoethyl chloride (5) completes the synthesis of butalamine (6).
Synthesis of butalamine
References
[edit]- ↑ Sterne J (April 1976). "[Butalamine hydrochloride. A new vasoactive substance]". Fortschritte Der Medizin (in German). 94 (11): 657–9. PMID 823083.
- ↑ Aron-samuel Jan Marcel Didier, FR3334M (1965 to Jan Marcel).
- ↑ Japan. Pat., 76 108 068, (1976); CA, 87, 5981b
- ↑ Aron-Samuel Jan Marcel Didier, Sterne Jean Jacques, U.S. patent 3,338,899 (1967 to).
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