Visnadine

Visnadine
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	C04AX24 (WHO) ;
Identifiers
	IUPAC name (9R,10R)-10-(acetyloxy)-8,8-dimethyl-2-oxo-9,10-dihydro-2H,8H-pyrano[2,3-f]chromen-9-yl (2R)-2-methylbutanoate;
CAS Number	477-32-7;
PubChem CID	442151;
ChemSpider	390669;
UNII	0RL4V0K263;
KEGG	D08735 ;
CompTox Dashboard (EPA)	DTXSID301023583 ;
ECHA InfoCard	100.006.833
Chemical and physical data
Formula	C21H24O7
Molar mass	388.416 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES CC[C@H](C(=O)O[C@H]1[C@@](OC2=C([C@H]1OC(=O)C)C3=C(C=CC(=O)O3)C=C2)(C)C)C;
	InChI InChI=1S/C21H24O7/c1-6-11(2)20(24)27-19-18(25-12(3)22)16-14(28-21(19,4)5)9-7-13-8-10-15(23)26-17(13)16/h7-11,18-19H,6H2,1-5H3/t11-,18-,19-/m1/s1; Key:GVBNSPFBYXGREE-CXWAGAITSA-N;
	(verify)

Visnadine (or visnadin) is a natural vasodilator.^[1] It was first isolated from bishop's weed (Ammi visnaga), a plant indigenous to the Mediterranean region which has been used for centuries in Egypt as a spasmolytic.^[2]

References

↑ Durate J, Vallejo I, Pérez-Vizcaino F, Jiménez R, Zarzuelo A, Tamargo J (June 1997). "Effects of visnadine on rat isolated vascular smooth muscles". Planta Medica. 63 (3). Thieme Medical Publishers: 233–6. doi:10.1055/s-2006-957660. PMID 9225605. S2CID 260248811.
↑ Smith E, Hosansky N, Bywater WG, van Tamelen EE (1957). "Constitution of Samidin, Dihydrosamidin and Visnadin". J. Am. Chem. Soc. 79 (13): 3534–3540. doi:10.1021/ja01570a062.

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[1] Durate J, Vallejo I, Pérez-Vizcaino F, Jiménez R, Zarzuelo A, Tamargo J (June 1997). "Effects of visnadine on rat isolated vascular smooth muscles". Planta Medica. 63 (3). Thieme Medical Publishers: 233–6. doi:10.1055/s-2006-957660. PMID 9225605. S2CID 260248811.

[2] Smith E, Hosansky N, Bywater WG, van Tamelen EE (1957). "Constitution of Samidin, Dihydrosamidin and Visnadin". J. Am. Chem. Soc. 79 (13): 3534–3540. doi:10.1021/ja01570a062.

[1]

[2]

v t e Peripheral vasodilators (C04)
Phenylethanolamine derivatives	Isoxsuprine Buphenine Bamethan
Alpha blockers	Non-selective Buflomedil Phentolamine Phenoxybenzamine Tolazoline Selective α₁-blockers Alfuzosin Doxazosin Prazosin Silodosin Tamsulosin Terazosin
Nicotinic acid and derivatives	Nicotinic acid Nicotinyl alcohol Inositol nicotinate Ciclonicate
Purine derivatives	Pentifylline Xantinol nicotinate Pentoxifylline Etofylline nicotinate
Ergot alkaloids	Ergoloid Nicergoline Dihydroergocristine
Other peripheral vasodilators	Cyclandelate Vincamine Moxisylyte Bencyclane Vinburnine Sulcotidil Naftidrofuryl Butalamine Visnadine Cetiedil Cinepazide Ifenprodil Azapetine Fasudil

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References