Fencamine
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| Clinical data | |
|---|---|
| Other names | Methamphetaminoethylcaffeine |
| Routes of administration | Oral |
| Drug class | Stimulant |
| ATC code |
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| Identifiers | |
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| CAS Number | |
| PubChem CID | |
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| Chemical and physical data | |
| Formula | C20H28N6O2 |
| Molar mass | 384.484 g·mol−1 |
| 3D model (JSmol) | |
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Fencamine, also known as methamphetaminoethylcaffeine, is a psychostimulant drug of the amphetamine class. It is closely related to fenethylline.[1] It is metabolized to methamphetamine and amphetamine.[2] The drug also contains a caffeine moiety in its chemical structure.
Fencamine has been experimentally used in the treatment of depression.[2] A clinical report on its use in prolonged reactive depression, an older psychiatric term referring to depressive conditions attributed to psychological stressors, was published in 1970.[3]
A 1974 study described a method for determining fencamine in rat and human urine.[4] According to a 2000 review summarizing the human results, approximately 32% of a 50 mg dose was excreted unchanged in urine within 48 hours.[2]
Names
[edit]The National Center for Advancing Translational Sciences Inxight Drugs database lists Altimina and Sicoclor as names for fencamine hydrochloride.[5]
Yet the United Nations Office on Drugs and Crime's Multilingual Dictionary of Narcotic Drugs and Psychotropic Substances lists these names under fencamfamin.[6]
Sicoclor was a registered medicinal product in Argentina until 2011.[7]
See also
[edit]References
[edit]- ↑ Cody JT (May 2002). "Precursor medications as a source of methamphetamine and/or amphetamine positive drug testing results". Journal of Occupational and Environmental Medicine. 44 (5): 435–50. doi:10.1097/00043764-200205000-00012. PMID 12024689. S2CID 44614179.
- 1 2 3 Musshoff F (February 2000). "Illegal or legitimate use? Precursor compounds to amphetamine and methamphetamine". Drug Metab Rev. 32 (1): 15–44. doi:10.1081/dmr-100100562. PMID 10711406.
- ↑ Quirós e Isla, P. G. (15 December 1970). "Acción del derivado etilendiamínico, fencamina, sobre depresiones reactivas prolongadas" [Effect of the ethylenediamine derivative, fencamine, on prolonged reactive depression]. Revista Clínica Española (in Spanish). 119 (5): 437–438. PMID 5505078.
- ↑ Mallol J, Pitarch L, Coronas R, Pons A Jr (September 1974). "Determination of dl-fencamine in rat and human urine". Arzneimittelforschung. 24 (9): 1301–1304. PMID 4154765.
- ↑ "Fencamine hydrochloride". Inxight Drugs. National Center for Advancing Translational Sciences. Retrieved 2026-09-23.
- ↑ United Nations Office on Drugs and Crime. "Part One". Multilingual Dictionary of Narcotic Drugs and Psychotropic Substances (PDF). p. 129.
- ↑ "Disposición 3520/2011" (PDF) (in Spanish). Administración Nacional de Medicamentos, Alimentos y Tecnología Médica. 17 May 2011. p. 4. Retrieved 25 September 2026.
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