STK38L

STK38L
Identifiers
Aliases	STK38L, NDR2, serine/threonine kinase 38 like
External IDs	OMIM: 615836; MGI: 1922250; HomoloGene: 56299; GeneCards: STK38L; OMA:STK38L - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PSB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 12 (human)
End	27,325,959 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	146,680,310 bp
RNA expression pattern
	Top expressed in
	ascending aorta; ; popliteal artery; ; tibial arteries; ; Achilles tendon; ; right coronary artery; ; Descending thoracic aorta; ; saphenous vein; ; left coronary artery; ; epithelium of colon; ; monocyte;
	Top expressed in
	ascending aorta; ; aortic valve; ; left colon; ; tail of embryo; ; facial motor nucleus; ; secondary oocyte; ; otolith organ; ; utricle; ; zygote; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	kinase activity; transferase activity; nucleotide binding; actin binding; protein serine/threonine kinase activity; protein kinase activity; protein binding; ATP binding; magnesium ion binding; metal ion binding;
Cellular component	cytoplasm; cytoskeleton; membrane; actin cytoskeleton; cytosol;
Biological process	protein phosphorylation; regulation of cellular component organization; intracellular signal transduction; peptidyl-serine phosphorylation; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23012
	232533
	ENSG00000211455
	ENSMUSG00000001630
	Q9Y2H1
	Q7TSE6
	NM_015000
	NM_172734; NM_001346666
	NP_055815
	NP_001333595; NP_766322
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 38-like is an enzyme that in humans is encoded by the STK38L gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000211455 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001630 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Suzuki A, Ogura T, Esumi H (May 2006). "NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling". J Biol Chem. 281 (20): 13915–21. doi:10.1074/jbc.M511354200. PMID 16488889.
↑ "Entrez Gene: STK38L serine/threonine kinase 38 like".

Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Stegert MR, Tamaskovic R, Bichsel SJ, et al. (2004). "Regulation of NDR2 protein kinase by multi-site phosphorylation and the S100B calcium-binding protein". J. Biol. Chem. 279 (22): 23806–12. doi:10.1074/jbc.M402472200. PMID 15037617.
Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2005). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases". Virology. 331 (1): 181–9. doi:10.1016/j.virol.2004.10.023. PMID 15582665.
Stegert MR, Hergovich A, Tamaskovic R, et al. (2006). "Regulation of NDR protein kinase by hydrophobic motif phosphorylation mediated by the mammalian Ste20-like kinase MST3". Mol. Cell. Biol. 25 (24): 11019–29. doi:10.1128/MCB.25.24.11019-11029.2005. PMC 1316964. PMID 16314523.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1) 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000211455 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000001630 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid16488889-5] Suzuki A, Ogura T, Esumi H (May 2006). "NDR2 acts as the upstream kinase of ARK5 during insulin-like growth factor-1 signaling". J Biol Chem. 281 (20): 13915–21. doi:10.1074/jbc.M511354200. PMID 16488889.

[entrez-6] "Entrez Gene: STK38L serine/threonine kinase 38 like".

[1]

[2]

[3]

[4]

[5]

[6]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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STK38L

References

Further reading