STK38

STK38
Identifiers
Aliases	STK38, NDR, NDR1, serine/threonine kinase 38
External IDs	OMIM: 606964; MGI: 2442572; HomoloGene: 56033; GeneCards: STK38; OMA:STK38 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1PSB
Enzyme activity
Gene location (Human)
Chr.	Chromosome 6 (human)
End	36,547,479 bp
Gene location (Mouse)
Chr.	Chromosome 17 (mouse)
End	29,226,969 bp
RNA expression pattern
	Top expressed in
	palpebral conjunctiva; ; oocyte; ; secondary oocyte; ; granulocyte; ; nasal epithelium; ; amniotic fluid; ; epithelium of nasopharynx; ; mononuclear cell; ; monocyte; ; mucosa of paranasal sinus;
	Top expressed in
	granulocyte; ; conjunctival fornix; ; thymus; ; blood; ; lacrimal gland; ; submandibular gland; ; spleen; ; body of femur; ; medullary collecting duct; ; ventricular zone;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	mitogen-activated protein kinase kinase kinase binding; transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding; metal ion binding; kinase activity; cadherin binding;
Cellular component	cytoplasm; nucleus; cytosol;
Biological process	protein phosphorylation; intracellular signal transduction; peptidyl-serine phosphorylation; negative regulation of MAP kinase activity; phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	11329
	106504
	ENSG00000112079
	ENSMUSG00000024006
	Q15208
	Q91VJ4
	NM_001305102; NM_007271
	NM_134115; NM_001357173
	NP_001292031; NP_009202
	NP_598876; NP_001344102
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase 38 is an enzyme that in humans is encoded by the STK38 gene.^[5]^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000112079 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024006 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Millward T, Cron P, Hemmings BA (Jun 1995). "Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase". Proc Natl Acad Sci U S A. 92 (11): 5022–6. Bibcode:1995PNAS...92.5022M. doi:10.1073/pnas.92.11.5022. PMC 41840. PMID 7761441.
↑ "Entrez Gene: STK38 serine/threonine kinase 38".

Tripodis N, Mason R, Humphray SJ, et al. (1999). "Physical map of human 6p21.2-6p21.3: region flanking the centromeric end of the major histocompatibility complex". Genome Res. 8 (6): 631–43. doi:10.1101/gr.8.6.631. PMC 310739. PMID 9647638.
Millward TA, Heizmann CW, Schäfer BW, Hemmings BA (1998). "Calcium regulation of Ndr protein kinase mediated by S100 calcium-binding proteins". EMBO J. 17 (20): 5913–22. doi:10.1093/emboj/17.20.5913. PMC 1170919. PMID 9774336.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Tamaskovic R, Bichsel SJ, Rogniaux H, et al. (2003). "Mechanism of Ca2+-mediated regulation of NDR protein kinase through autophosphorylation and phosphorylation by an upstream kinase". J. Biol. Chem. 278 (9): 6710–8. doi:10.1074/jbc.M210590200. PMID 12493777.
Mungall AJ, Palmer SA, Sims SK, et al. (2003). "The DNA sequence and analysis of human chromosome 6". Nature. 425 (6960): 805–11. Bibcode:2003Natur.425..805M. doi:10.1038/nature02055. PMID 14574404.
Bhattacharya S, Large E, Heizmann CW, et al. (2004). "Structure of the Ca2+/S100B/NDR kinase peptide complex: insights into S100 target specificity and activation of the kinase". Biochemistry. 42 (49): 14416–26. doi:10.1021/bi035089a. PMID 14661952.
Devroe E, Erdjument-Bromage H, Tempst P, Silver PA (2004). "Human Mob proteins regulate the NDR1 and NDR2 serine-threonine kinases". J. Biol. Chem. 279 (23): 24444–51. doi:10.1074/jbc.M401999200. PMID 15067004.
Bichsel SJ, Tamaskovic R, Stegert MR, Hemmings BA (2005). "Mechanism of activation of NDR (nuclear Dbf2-related) protein kinase by the hMOB1 protein". J. Biol. Chem. 279 (34): 35228–35. doi:10.1074/jbc.M404542200. PMID 15197186.
Jin J, Smith FD, Stark C, et al. (2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". Curr. Biol. 14 (16): 1436–50. Bibcode:2004CBio...14.1436J. doi:10.1016/j.cub.2004.07.051. PMID 15324660. S2CID 2371325.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Devroe E, Silver PA, Engelman A (2005). "HIV-1 incorporates and proteolytically processes human NDR1 and NDR2 serine-threonine kinases". Virology. 331 (1): 181–9. doi:10.1016/j.virol.2004.10.023. PMID 15582665.
Amente S, Napolitano G, Licciardo P, et al. (2005). "Identification of proteins interacting with the RNAPII FCP1 phosphatase: FCP1 forms a complex with arginine methyltransferase PRMT5 and it is a substrate for PRMT5-mediated methylation". FEBS Lett. 579 (3): 683–9. Bibcode:2005FEBSL.579..683A. doi:10.1016/j.febslet.2004.12.045. PMID 15670829. S2CID 33475235.
Hergovich A, Bichsel SJ, Hemmings BA (2005). "Human NDR kinases are rapidly activated by MOB proteins through recruitment to the plasma membrane and phosphorylation". Mol. Cell. Biol. 25 (18): 8259–72. doi:10.1128/MCB.25.18.8259-8272.2005. PMC 1234321. PMID 16135814.
Hergovich A, Lamla S, Nigg EA, Hemmings BA (2007). "Centrosome-associated NDR kinase regulates centrosome duplication". Mol. Cell. 25 (4): 625–34. doi:10.1016/j.molcel.2007.01.020. PMID 17317633.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human Serine/threonine-protein kinase 38

This article on a gene on human chromosome 6 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000112079 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024006 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7761441-5] Millward T, Cron P, Hemmings BA (Jun 1995). "Molecular cloning and characterization of a conserved nuclear serine(threonine) protein kinase". Proc Natl Acad Sci U S A. 92 (11): 5022–6. Bibcode:1995PNAS...92.5022M. doi:10.1073/pnas.92.11.5022. PMC 41840. PMID 7761441.

[entrez-6] "Entrez Gene: STK38 serine/threonine kinase 38".

[1]

[2]

[3]

[4]

[5]

[6]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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STK38

References

Further reading

External links