SIK3

SIK3
Identifiers
Aliases	SIK3, QSK, SIK-3, L19, KIAA0999, SIK family kinase 3, SEMDK
External IDs	OMIM: 614776; MGI: 2446296; HomoloGene: 57023; GeneCards: SIK3; OMA:SIK3 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 11 (human)
End	117,098,437 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	46,135,492 bp
RNA expression pattern
	Top expressed in
	external globus pallidus; ; corpus callosum; ; lateral nuclear group of thalamus; ; pars reticulata; ; sperm; ; pars compacta; ; inferior ganglion of vagus nerve; ; ventral tegmental area; ; middle frontal gyrus; ; subthalamic nucleus;
	Top expressed in
	substantia nigra; ; lumbar subsegment of spinal cord; ; medial geniculate nucleus; ; medial dorsal nucleus; ; lateral geniculate nucleus; ; median eminence; ; arcuate nucleus; ; ciliary body; ; nucleus accumbens; ; inferior colliculi;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; protein binding; ATP binding; magnesium ion binding; metal ion binding; kinase activity; tau-protein kinase activity;
Cellular component	cytoplasm; nucleoplasm;
Biological process	protein phosphorylation; phosphorylation; microtubule cytoskeleton organization; intracellular signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	23387
	70661
	ENSG00000160584
	ENSMUSG00000034135
	Q9Y2K2
	Q6P4S6
	NM_001281748; NM_001281749; NM_025164; NM_001366686; NM_001366687
	NM_027498
	NP_001268677; NP_001268678; NP_079440; NP_001353615; NP_001353616
	NP_081774
	Wikidata
View/Edit Human	View/Edit Mouse

Serine/threonine-protein kinase SIK3 is an enzyme that in humans is encoded by the SIK3 gene.^[5]^[6]^[7] It enhances TORC1 and TORC2 signaling, along with protein phosphorylation.^[7] It is part of the salt-inducible kinase family

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000160584 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034135 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.
↑ Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.
1 2 "Entrez Gene: KIAA0999 KIAA0999 protein".

Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T (June 2002). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Research. 9 (3): 99–106. CiteSeerX 10.1.1.500.923. doi:10.1093/dnares/9.3.99. PMID 12168954.
Lizcano JM, Göransson O, Toth R, Deak M, Morrice NA, Boudeau J, Hawley SA, Udd L, Mäkelä TP, Hardie DG, Alessi DR (February 2004). "LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1". The EMBO Journal. 23 (4): 833–43. doi:10.1038/sj.emboj.7600110. PMC 381014. PMID 14976552.
Petroziello J, Yamane A, Westendorf L, Thompson M, McDonagh C, Cerveny C, Law CL, Wahl A, Carter P (October 2004). "Suppression subtractive hybridization and expression profiling identifies a unique set of genes overexpressed in non-small-cell lung cancer". Oncogene. 23 (46): 7734–45. doi:10.1038/sj.onc.1207921. PMID 15334068.
Al-Hakim AK, Göransson O, Deak M, Toth R, Campbell DG, Morrice NA, Prescott AR, Alessi DR (December 2005). "14-3-3 cooperates with LKB1 to regulate the activity and localization of QSK and SIK". Journal of Cell Science. 118 (Pt 23): 5661–73. doi:10.1242/jcs.02670. PMID 16306228.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000160584 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034135 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10231032-5] Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O (February 1999). "Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Research. 6 (1): 63–70. doi:10.1093/dnares/6.1.63. PMID 10231032.

[pmid8889548-6] Bonaldo MF, Lennon G, Soares MB (September 1996). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Research. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548.

[entrez-7] 1 2 "Entrez Gene: KIAA0999 KIAA0999 protein".

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v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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SIK3

References

Further reading