DAPK2

DAPK2
Identifiers
Aliases	DAPK2, DRP-1, DRP1, death-associated protein kinase 2, death associated protein kinase 2
External IDs	OMIM: 616567; MGI: 1341297; HomoloGene: 74940; GeneCards: DAPK2; OMA:DAPK2 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1WMK, 1WRZ, 1Z9X, 1ZUZ, 1ZWS, 2A27, 2A2A, 2CKE
Enzyme activity
Gene location (Human)
Chr.	Chromosome 15 (human)
End	64,072,033 bp
Gene location (Mouse)
Chr.	Chromosome 9 (mouse)
End	66,272,242 bp
RNA expression pattern
	Top expressed in
	right lobe of thyroid gland; ; left lobe of thyroid gland; ; right auricle of heart; ; right lung; ; gastrocnemius muscle; ; muscle of thigh; ; upper lobe of left lung; ; left ventricle; ; blood; ; sural nerve;
	Top expressed in
	muscle of thigh; ; membranous bone; ; body of femur; ; lumbar spinal ganglion; ; Dermatocranium; ; maxilla; ; lip; ; right lung; ; right lung lobe; ; tibiofemoral joint;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; nucleotide binding; protein kinase activity; calmodulin binding; kinase activity; protein serine/threonine kinase activity; protein binding; identical protein binding; ATP binding;
Cellular component	cytoplasm; autophagosome lumen; cytoplasmic vesicle; Golgi apparatus; intracellular membrane-bounded organelle; nucleus;
Biological process	regulation of apoptotic process; intracellular signal transduction; regulation of intrinsic apoptotic signaling pathway; phosphorylation; protein phosphorylation; positive regulation of eosinophil chemotaxis; regulation of autophagy; anoikis; positive regulation of neutrophil chemotaxis; protein autophosphorylation; neutrophil migration; apoptotic process; peptidyl-serine phosphorylation; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	23604
	13143
	ENSG00000035664
	ENSMUSG00000032380
	Q9UIK4
	Q8VDF3
NM_014326; NM_001363730; NM_001384997; NM_001384998; NM_001384999;
	NM_001385000
	NM_010019
	NP_055141; NP_001350659
	NP_034149; NP_001391612
	Wikidata
View/Edit Human	View/Edit Mouse

Death-associated protein kinase 2 is an enzyme that in humans is encoded by the DAPK2 gene.^[5]^[6]

This gene encodes a protein that belongs to the serine/threonine protein kinase family. This protein contains a N-terminal protein kinase domain followed by a conserved calmodulin-binding domain with significant similarity to that of death-associated protein kinase 1 (DAPK1), a positive regulator of programmed cell death. Gene overexpression induces cell apoptosis. It uses multiple polyadenylation sites.^[6]

The DAPK2 mRNA may undergo alternative splicing to produce a DAPK3-like encoding transcript.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000035664 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032380 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, et al. (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene. 18 (23): 3471–3480. doi:10.1038/sj.onc.1202701. PMID 10376525. S2CID 19035227.
1 2 "Entrez Gene: DAPK2 death-associated protein kinase 2".
↑ Shoval Y, Berissi H, Kimchi A, Pietrokovski S (Mar 2011). "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". PLOS ONE. 6 (2) e17344. Bibcode:2011PLoSO...617344S. doi:10.1371/journal.pone.0017344. PMC 3050894. PMID 21408167.

Inbal B, Shani G, Cohen O, Kissil JL, Kimchi A (Feb 2000). "Death-Associated Protein Kinase-Related Protein 1, a Novel Serine/Threonine Kinase Involved in Apoptosis". Molecular and Cellular Biology. 20 (3): 1044–1054. doi:10.1128/MCB.20.3.1044-1054.2000. PMC 85221. PMID 10629061.
Shani G, Henis-Korenblit S, Jona G, Gileadi O, Eisenstein M, Ziv T, et al. (Mar 2001). "Autophosphorylation restrains the apoptotic activity of DRP-1 kinase by controlling dimerization and calmodulin binding". The EMBO Journal. 20 (5): 1099–1113. doi:10.1093/emboj/20.5.1099. PMC 145456. PMID 11230133.
Wong TS, Chang HW, Tang KC, Wei WI, Kwong DL, Sham JS, et al. (Feb 2002). "High frequency of promoter hypermethylation of the death-associated protein-kinase gene in nasopharyngeal carcinoma and its detection in the peripheral blood of patients". Clinical Cancer Research. 8 (2): 433–437. PMID 11839660.
Chan MW, Chan LW, Tang NL, Tong JH, Lo KW, Lee TL, et al. (Feb 2002). "Hypermethylation of multiple genes in tumor tissues and voided urine in urinary bladder cancer patients". Clinical Cancer Research. 8 (2): 464–470. PMID 11839665.
Inbal B, Bialik S, Sabanay I, Shani G, Kimchi A (Apr 2002). "DAP kinase and DRP-1 mediate membrane blebbing and the formation of autophagic vesicles during programmed cell death". The Journal of Cell Biology. 157 (3): 455–468. doi:10.1083/jcb.200109094. PMC 2173279. PMID 11980920.
Satoh A, Toyota M, Itoh F, Kikuchi T, Obata T, Sasaki Y, et al. (Jun 2002). "DNA methylation and histone deacetylation associated with silencing DAP kinase gene expression in colorectal and gastric cancers". British Journal of Cancer. 86 (11): 1817–1823. doi:10.1038/sj.bjc.6600319. PMC 2375414. PMID 12087472.
Barrios-Rodiles M, Brown KR, Ozdamar B, Bose R, Liu Z, Donovan RS, et al. (Mar 2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–1625. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, et al. (Nov 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–648. doi:10.1016/j.cell.2006.09.026. PMID 17081983.
Rizzi M, Tschan MP, Britschgi C, Britschgi A, Hugli B, Grob TJ, et al. (Jun 2007). "The death-associated protein kinase 2 is up-regulated during normal myeloid differentiation and enhances neutrophil maturation in myeloid leukemic cells". Journal of Leukocyte Biology. 81 (6): 1599–1608. doi:10.1189/jlb.0606400. PMID 17347302.

This article on a gene on human chromosome 15 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000035664 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000032380 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[Kawai_1999-5] Kawai T, Nomura F, Hoshino K, Copeland NG, Gilbert DJ, Jenkins NA, et al. (Jun 1999). "Death-associated protein kinase 2 is a new calcium/calmodulin-dependent protein kinase that signals apoptosis through its catalytic activity". Oncogene. 18 (23): 3471–3480. doi:10.1038/sj.onc.1202701. PMID 10376525. S2CID 19035227.

[entrez-6] 1 2 "Entrez Gene: DAPK2 death-associated protein kinase 2".

[PLoS_One-7] Shoval Y, Berissi H, Kimchi A, Pietrokovski S (Mar 2011). "New Modularity of DAP-Kinases: Alternative Splicing of the DRP-1 Gene Produces a ZIPk-Like Isoform". PLOS ONE. 6 (2) e17344. Bibcode:2011PLoSO...617344S. doi:10.1371/journal.pone.0017344. PMC 3050894. PMID 21408167.

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

This page was redesigned at the edge.

DAPK2

References

Further reading