Lysosomal trafficking regulator

lysosomal trafficking regulator
lysosomal trafficking regulator
Identifiers
Symbol	LYST
Alt. symbols	CHS1
NCBI gene	1130
HGNC	1968
OMIM	606897
RefSeq	NM_000081
UniProt	Q99698
Other data
Locus	Chr. 1 q42.1-42.2
Structures
Search for
Structures	Swiss-model
Domains	InterPro

LYST
Identifiers
Aliases	LYST, lysosomal trafficking regulator, CHS, CHS1, Mauve
External IDs	OMIM: 606897; MGI: 107448; HomoloGene: 61; GeneCards: LYST; OMA:LYST - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	235,883,640 bp
Gene location (Mouse)
Chr.	Chromosome 13 (mouse)
End	13,953,388 bp
RNA expression pattern
	Top expressed in
	monocyte; ; nipple; ; trabecular bone; ; bone marrow; ; blood; ; pylorus; ; bone marrow cell; ; skin of thigh; ; cardia; ; Achilles tendon;
	Top expressed in
	granulocyte; ; tibiofemoral joint; ; lumbar spinal ganglion; ; mesenteric lymph nodes; ; facial motor nucleus; ; iris; ; dentate gyrus of hippocampal formation granule cell; ; blood; ; secondary oocyte; ; stroma of bone marrow;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding;
Cellular component	cytoplasm; microtubule cytoskeleton;
Biological process	protein transport; pigmentation; melanosome organization; endosome to lysosome transport via multivesicular body sorting pathway; lysosome organization; defense response to bacterium; defense response to virus; leukocyte chemotaxis; natural killer cell mediated cytotoxicity; mast cell secretory granule organization; defense response to protozoan;
	Sources:Amigo / QuickGO
Orthologs
	1130
	17101
	ENSG00000143669
	ENSMUSG00000019726
	Q99698
	P97412
	NM_000081; NM_001005736; NM_001301365
	NM_010748
	NP_000072; NP_001288294
	NP_034878
	Wikidata
View/Edit Human	View/Edit Mouse

Lysosomal trafficking regulator is a vesicular transport protein associated with Chédiak–Higashi syndrome.

In melanocytic cells LYST gene expression may be regulated by MITF.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000143669 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000019726 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hoek KS, Schlegel NC, Eichhoff OM, et al. (2008). "Novel MITF targets identified using a two-step DNA microarray strategy". Pigment Cell Melanoma Res. 21 (6): 665–76. doi:10.1111/j.1755-148X.2008.00505.x. PMID 19067971.

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