STX17

STX17
Identifiers
Aliases	STX17, syntaxin 17
External IDs	OMIM: 604204; MGI: 1914977; HomoloGene: 9917; GeneCards: STX17; OMA:STX17 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4WY4,%%s4WY4
Gene location (Human) Chr. Chromosome 9 (human) Band 9q31.1 Start 99,906,654 bp End 99,974,534 bp
Gene location (Mouse) Chr. Chromosome 4 (mouse) Band 4|4 B1 Start 48,124,915 bp End 48,186,507 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in nipple secondary oocyte Achilles tendon pylorus skin of hip corpus epididymis caput epididymis tail of epididymis trabecular bone cardia Top expressed in parotid gland ciliary body saccule zygote interventricular septum spermatocyte retinal pigment epithelium lumbar subsegment of spinal cord seminiferous tubule iris More reference expression data BioGPS n/a
Gene ontology Molecular function SNAP receptor activity protein binding protein phosphatase binding protein kinase binding SNARE binding Cellular component HOPS complex cytoplasm integral component of membrane cytosol mitochondria associated membranes rough endoplasmic reticulum endoplasmic reticulum membrane membrane lysosomal membrane autophagosome membrane SNARE complex smooth endoplasmic reticulum membrane endoplasmic reticulum mitochondrion ER to Golgi transport vesicle membrane COPII-coated ER to Golgi transport vesicle endoplasmic reticulum-Golgi intermediate compartment membrane cytoplasmic vesicle endoplasmic reticulum-Golgi intermediate compartment autophagosome plasma membrane endomembrane system Biological process endoplasmic reticulum-Golgi intermediate compartment organization Golgi organization protein localization to phagophore assembly site autophagy endoplasmic reticulum to Golgi vesicle-mediated transport vesicle docking autophagosome maturation intracellular protein transport vesicle fusion vesicle-mediated transport autophagosome membrane docking exocytosis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 55014 67727 Ensembl ENSG00000136874 ENSMUSG00000061455 UniProt P56962 Q9D0I4 RefSeq (mRNA) NM_017919 NM_026343 RefSeq (protein) NP_060389 NP_080619 Location (UCSC) Chr 9: 99.91 – 99.97 Mb Chr 4: 48.12 – 48.19 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Syntaxin 17 is a protein that in humans is encoded by the STX17 gene. In horses a duplication in intron 6 causes progressive graying.

See also

• Syntaxin

Further reading

• Itakura E, Kishi-Itakura C, Mizushima N (2012). "The hairpin-type tail-anchored SNARE syntaxin 17 targets to autophagosomes for fusion with endosomes/lysosomes". Cell. 151 (6): 1256–69. doi:10.1016/j.cell.2012.11.001. PMID 23217709.
• Petukhova L, Duvic M, Hordinsky M, Norris D, Price V, Shimomura Y, Kim H, Singh P, Lee A, Chen WV, Meyer KC, Paus R, Jahoda CA, Amos CI, Gregersen PK, Christiano AM (2010). "Genome-wide association study in alopecia areata implicates both innate and adaptive immunity". Nature. 466 (7302): 113–7. Bibcode:2010Natur.466..113P. doi:10.1038/nature09114. PMC 2921172. PMID 20596022.
• Muppirala M, Gupta V, Swarup G (2011). "Syntaxin 17 cycles between the ER and ERGIC and is required to maintain the architecture of ERGIC and Golgi". Biol. Cell. 103 (7): 333–50. doi:10.1042/BC20110006. PMID 21545355. S2CID 41507139.
• Zhao ZZ, Duffy DL, Thomas SA, Martin NG, Hayward NK, Montgomery GW (2009). "Polymorphisms in the syntaxin 17 gene are not associated with human cutaneous malignant melanoma". Melanoma Res. 19 (2): 80–6. doi:10.1097/CMR.0b013e328322fc45. PMC 3665505. PMID 19209086.
• Steegmaier M, Yang B, Yoo JS, Huang B, Shen M, Yu S, Luo Y, Scheller RH (1998). "Three novel proteins of the syntaxin/SNAP-25 family". J. Biol. Chem. 273 (51): 34171–9. doi:10.1074/jbc.273.51.34171. PMID 9852078.
• Hay JC, Chao DS, Kuo CS, Scheller RH (1997). "Protein interactions regulating vesicle transport between the endoplasmic reticulum and Golgi apparatus in mammalian cells". Cell. 89 (1): 149–58. doi:10.1016/s0092-8674(00)80191-9. PMID 9094723. S2CID 8682509.
• Steegmaier M, Oorschot V, Klumperman J, Scheller RH (2000). "Syntaxin 17 is abundant in steroidogenic cells and implicated in smooth endoplasmic reticulum membrane dynamics". Mol. Biol. Cell. 11 (8): 2719–31. doi:10.1091/mbc.11.8.2719. PMC 14951. PMID 10930465.

External links

• Overview of all the structural information available in the PDB for UniProt: P56962 (Human Syntaxin-17 (STX17)) at the PDBe-KB.