AP3D1

AP3D1
Identifiers
Aliases	AP3D1, ADTD, hBLVR, adaptor related protein complex 3 delta 1 subunit, HPS10, adaptor related protein complex 3 subunit delta 1
External IDs	OMIM: 607246; MGI: 107734; HomoloGene: 2926; GeneCards: AP3D1; OMA:AP3D1 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4AFI
Gene location (Human) Chr. Chromosome 19 (human) Band 19p13.3 Start 2,100,988 bp End 2,164,468 bp
Gene location (Mouse) Chr. Chromosome 10 (mouse) Band 10 C1|10 39.72 cM Start 80,542,790 bp End 80,578,098 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii anterior pituitary lateral nuclear group of thalamus parotid gland beta cell cerebellar vermis stromal cell of endometrium pylorus pars compacta frontal pole Top expressed in Ileal epithelium vestibular membrane of cochlear duct anterior amygdaloid area ventromedial nucleus facial motor nucleus arcuate nucleus habenula subiculum medial dorsal nucleus lateral hypothalamus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transporter activity Cellular component cytoplasm Golgi apparatus membrane Golgi membrane axon lysosomal membrane terminal bouton membrane coat endosome membrane axon cytoplasm AP-3 adaptor complex presynaptic endosome plasma membrane presynapse postsynapse glutamatergic synapse Biological process protein localization to organelle protein localization to membrane antigen processing and presentation eye pigment biosynthetic process anterograde axonal transport melanosome organization synaptic vesicle membrane organization endosome to melanosome transport protein transport regulation of sequestering of zinc ion antigen processing and presentation, exogenous lipid antigen via MHC class Ib positive regulation of NK T cell differentiation anterograde synaptic vesicle transport intracellular protein transport vesicle-mediated transport synaptic vesicle budding from endosome neurotransmitter receptor transport, postsynaptic endosome to lysosome transport protein targeting to vacuole Golgi to vacuole transport vesicle-mediated transport in synapse Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8943 11776 Ensembl ENSG00000065000 ENSMUSG00000020198 UniProt O14617 O54774 RefSeq (mRNA) NM_001077523 NM_001261826 NM_003938 NM_001374799 NM_007460 RefSeq (protein) NP_001248755 NP_003929 NP_001361728 NP_031486 Location (UCSC) Chr 19: 2.1 – 2.16 Mb Chr 10: 80.54 – 80.58 Mb PubMed search
Wikidata
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AP-3 complex subunit delta-1 is a protein that in humans is encoded by the AP3D1 gene.

Function

AP3D1 is a subunit of the AP3 adaptor-like complex, which is not associated with clathrin. The AP3D1 subunit is implicated in intracellular biogenesis and trafficking of pigment granules and possibly platelet dense granules and neurotransmitter vesicles.[supplied by OMIM]

Interactions

AP3D1 has been shown to interact with SYBL1.

External links

• Human AP3D1 genome location and AP3D1 gene details page in the UCSC Genome Browser.

Further reading

• Höning S, Sandoval IV, von Figura K (Aug 1998). "A di-leucine-based motif in the cytoplasmic tail of LIMP-II and tyrosinase mediates selective binding of AP-3". The EMBO Journal. 17 (5): 1304–14. doi:10.1093/emboj/17.5.1304. PMC 1170479. PMID 9482728.
• Kantheti P, Qiao X, Diaz ME, Peden AA, Meyer GE, Carskadon SL, Kapfhamer D, Sufalko D, Robinson MS, Noebels JL, Burmeister M (Jul 1998). "Mutation in AP-3 delta in the mocha mouse links endosomal transport to storage deficiency in platelets, melanosomes, and synaptic vesicles". Neuron. 21 (1): 111–22. doi:10.1016/S0896-6273(00)80519-X. PMID 9697856. S2CID 17237941.
• Rehling P, Darsow T, Katzmann DJ, Emr SD (2000). "Formation of AP-3 transport intermediates requires Vps41 function". Nature Cell Biology. 1 (6): 346–53. doi:10.1038/14037. PMID 10559961. S2CID 24932376.
• Craig HM, Reddy TR, Riggs NL, Dao PP, Guatelli JC (May 2000). "Interactions of HIV-1 nef with the mu subunits of adaptor protein complexes 1, 2, and 3: role of the dileucine-based sorting motif". Virology. 271 (1): 9–17. doi:10.1006/viro.2000.0277. PMID 10814565.
• Crump CM, Xiang Y, Thomas L, Gu F, Austin C, Tooze SA, Thomas G (May 2001). "PACS-1 binding to adaptors is required for acidic cluster motif-mediated protein traffic". The EMBO Journal. 20 (9): 2191–201. doi:10.1093/emboj/20.9.2191. PMC 125242. PMID 11331585.
• Austin C, Boehm M, Tooze SA (Apr 2002). "Site-specific cross-linking reveals a differential direct interaction of class 1, 2, and 3 ADP-ribosylation factors with adaptor protein complexes 1 and 3". Biochemistry. 41 (14): 4669–77. doi:10.1021/bi016064j. PMID 11926829.
• Janvier K, Craig H, Hitchin D, Madrid R, Sol-Foulon N, Renault L, Cherfils J, Cassel D, Benichou S, Guatelli J (Mar 2003). "HIV-1 Nef stabilizes the association of adaptor protein complexes with membranes". The Journal of Biological Chemistry. 278 (10): 8725–32. doi:10.1074/jbc.M210115200. PMID 12486136.
• Nie Z, Boehm M, Boja ES, Vass WC, Bonifacino JS, Fales HM, Randazzo PA (Sep 2003). "Specific regulation of the adaptor protein complex AP-3 by the Arf GAP AGAP1". Developmental Cell. 5 (3): 513–21. doi:10.1016/S1534-5807(03)00234-X. PMID 12967569.
• Salazar G, Love R, Werner E, Doucette MM, Cheng S, Levey A, Faundez V (Feb 2004). "The zinc transporter ZnT3 interacts with AP-3 and it is preferentially targeted to a distinct synaptic vesicle subpopulation". Molecular Biology of the Cell. 15 (2): 575–87. doi:10.1091/mbc.E03-06-0401. PMC 329249. PMID 14657250.
• Lefrançois S, Janvier K, Boehm M, Ooi CE, Bonifacino JS (Oct 2004). "An ear-core interaction regulates the recruitment of the AP-3 complex to membranes". Developmental Cell. 7 (4): 619–25. doi:10.1016/j.devcel.2004.08.009. PMID 15469849.
• Coleman SH, Van Damme N, Day JR, Noviello CM, Hitchin D, Madrid R, Benichou S, Guatelli JC (Feb 2005). "Leucine-specific, functional interactions between human immunodeficiency virus type 1 Nef and adaptor protein complexes". Journal of Virology. 79 (4): 2066–78. doi:10.1128/JVI.79.4.2066-2078.2005. PMC 546596. PMID 15681409.
• Dong X, Li H, Derdowski A, Ding L, Burnett A, Chen X, Peters TR, Dermody TS, Woodruff E, Wang JJ, Spearman P (Mar 2005). "AP-3 directs the intracellular trafficking of HIV-1 Gag and plays a key role in particle assembly". Cell. 120 (5): 663–74. doi:10.1016/j.cell.2004.12.023. PMID 15766529. S2CID 14528434.
• Theos AC, Tenza D, Martina JA, Hurbain I, Peden AA, Sviderskaya EV, Stewart A, Robinson MS, Bennett DC, Cutler DF, Bonifacino JS, Marks MS, Raposo G (2006). "Functions of adaptor protein (AP)-3 and AP-1 in tyrosinase sorting from endosomes to melanosomes". Molecular Biology of the Cell. 16 (11): 5356–72. doi:10.1091/mbc.E05-07-0626. PMC 1266432. PMID 16162817.