Casein kinase 1, alpha 1

CSNK1A1
Identifiers
Aliases	CSNK1A1, CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975, casein kinase 1 alpha 1
External IDs	OMIM: 600505; MGI: 1934950; HomoloGene: 111694; GeneCards: CSNK1A1; OMA:CSNK1A1 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	5FQD
Enzyme activity
Gene location (Human)
Chr.	Chromosome 5 (human)
End	149,551,471 bp
Gene location (Mouse)
Chr.	Chromosome 18 (mouse)
End	61,723,132 bp
RNA expression pattern
	Top expressed in
	stromal cell of endometrium; ; islet of Langerhans; ; gallbladder; ; ganglionic eminence; ; smooth muscle tissue; ; epithelium of colon; ; ventricular zone; ; nipple; ; Achilles tendon; ; pylorus;
	Top expressed in
	renal corpuscle; ; atrioventricular valve; ; cumulus cell; ; medullary collecting duct; ; medial ganglionic eminence; ; left lung lobe; ; Gonadal ridge; ; molar; ; endocardial cushion; ; pineal gland;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; protein kinase activity; nucleotide binding; protein binding; ATP binding; kinase activity; protein serine/threonine kinase activity;
Cellular component	cytoplasm; centrosome; nuclear speck; mRNA cleavage and polyadenylation specificity factor complex; membrane; keratin filament; chromosome; microtubule organizing center; chromosome, centromeric region; cytoskeleton; beta-catenin destruction complex; kinetochore; nucleus; cytosol; cilium; cell projection; ciliary basal body; ribonucleoprotein complex;
Biological process	regulation of GTP binding; Golgi organization; phosphorylation; cell division; protein phosphorylation; cell surface receptor signaling pathway; peptidyl-serine phosphorylation; phagocytosis; intermediate filament cytoskeleton organization; cell cycle; negative regulation of canonical Wnt signaling pathway; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; signal transduction; proteasome-mediated ubiquitin-dependent protein catabolic process; beta-catenin destruction complex assembly; regulation of cell shape; beta-catenin destruction complex disassembly; Wnt signaling pathway; cell morphogenesis; peptidyl-threonine phosphorylation;
	Sources:Amigo / QuickGO
Orthologs
	1452
	93687
	ENSG00000113712
	ENSMUSG00000024576
	P48729
	Q6PJ87
	NM_001025105; NM_001271741; NM_001271742; NM_001892
	NM_146087; NM_001357498; NM_001357499; NM_001357500
	NP_001020276; NP_001258670; NP_001258671; NP_001883
	NP_666199; NP_001344427; NP_001344428; NP_001344429
	Wikidata
View/Edit Human	View/Edit Mouse

Casein kinase I isoform alpha is an enzyme that in humans is encoded by the CSNK1A1 gene.^[5]

Interactions

Casein kinase 1, alpha 1 has been shown to interact with Centaurin, alpha 1^[6]^[7] and AXIN1.^[8]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000113712 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024576 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Tapia C, Featherstone T, Gómez C, Taillon-Miller P, Allende CC, Allende JE (Aug 1994). "Cloning and chromosomal localization of the gene coding for human protein kinase CK1". FEBS Letters. 349 (2): 307–12. doi:10.1016/0014-5793(94)00679-2. PMID 8050587. S2CID 19071414.
↑ Dubois T, Howell S, Zemlickova E, Aitken A (Apr 2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS Letters. 517 (1–3): 167–71. doi:10.1016/S0014-5793(02)02614-5. PMID 12062430. S2CID 84792445.
↑ Dubois T, Kerai P, Zemlickova E, Howell S, Jackson TR, Venkateswarlu K, Cullen PJ, Theibert AB, Larose L, Roach PJ, Aitken A (Jun 2001). "Casein kinase I associates with members of the centaurin-alpha family of phosphatidylinositol 3,4,5-trisphosphate-binding proteins". The Journal of Biological Chemistry. 276 (22): 18757–64. doi:10.1074/jbc.M010005200. PMID 11278595.
↑ Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC (May 2002). "Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways". The Journal of Biological Chemistry. 277 (20): 17706–12. doi:10.1074/jbc.M111982200. PMID 11884395.

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Casein kinase 1, alpha 1

Interactions

See also

References

Further reading