ML398

ML398
Clinical data
Other names	ML-398
Drug class	Dopamine D4 receptor antagonist
ATC code	None;
Identifiers
	IUPAC name (2R)-4-[(4-chlorophenyl)methyl]-2-(2-phenylethyl)morpholine;
PubChem CID	72737723;
IUPHAR/BPS	8440;
ChemSpider	35033271;
ChEMBL	ChEMBL3335556;
Chemical and physical data
Formula	C19H22ClNO
Molar mass	315.84 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES C1CO[C@@H](CN1CC2=CC=C(C=C2)Cl)CCC3=CC=CC=C3;
	InChI InChI=1S/C19H22ClNO/c20-18-9-6-17(7-10-18)14-21-12-13-22-19(15-21)11-8-16-4-2-1-3-5-16/h1-7,9-10,19H,8,11-15H2/t19-/m1/s1; Key:CVKXGRRJHJHUFY-LJQANCHMSA-N;

ML398 is a potent and selective dopamine D₄ receptor antagonist which has been used in scientific research.^[1]^[2]^[3] It shows high affinity for the dopamine D₄ receptor (K_i = 36 nM) and negligible affinity for other four dopamine receptors (>20,000 nM).^[2]^[3] As such, the drug shows more than 100-fold selectivity for the dopamine D₄ receptor over the other dopamine receptors.^[2]^[3] It has been found to reverse cocaine-induced hyperlocomotion.^[2] The chemical synthesis of ML398 has been described.^[2]^[4] ML398 was first described in the scientific literature by 2014.^[2]

References

↑ "Delving into the Latest Updates on ML-398 with Synapse". Synapse. 23 May 2026. Retrieved 7 July 2026.
1 2 3 4 5 6 Berry CB, Bubser M, Jones CK, Hayes JP, Wepy JA, Locuson CW, et al. (September 2014). "Discovery and Characterization of ML398, a Potent and Selective Antagonist of the D4 Receptor with in Vivo Activity". ACS Medicinal Chemistry Letters. 5 (9): 1060–1064. doi:10.1021/ml500267c. PMC 4160761. PMID 25221667.
1 2 3 Berry CB, Locuson CW, Daniels JS, Lindsley CW, Hopkins CR (2015). "Discovery and characterization of ML398, a potent and selective chiral morpholine based antagonist of the dopamine 4 (D4) receptor". Probe Reports from the NIH Molecular Libraries Program. PMID 25834901.
↑ Torres S, Velasco M, Gallegos-Rojas JÁ, Bernès S, Orea ML, Terán JL, et al. (2019). "A Concise Stereoselective Synthesis of ( R )-2-Benzylmorpholine and ML398 from ( R )-(−)-2-Phenylglycinol". Journal of Heterocyclic Chemistry. 56 (9): 2677–2682. doi:10.1002/jhet.3657. ISSN 0022-152X.

This drug article relating to the nervous system is a stub. You can help Wikipedia by adding missing information.