KRT77

KRT77
Identifiers
Aliases	KRT77, K1B, KRT1B, keratin 77
External IDs	OMIM: 611158; MGI: 3588209; GeneCards: KRT77
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,703,524 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,778,140 bp
RNA expression pattern
	Top expressed in
	skin of arm; ; skin of thigh; ; nipple; ; skin of hip; ; skin of abdomen; ; vulva; ; testicle; ; human penis; ; gonad; ; gastrocnemius muscle;
	Top expressed in
	skin of abdomen; ; skin of external ear; ; skin of back; ; lip; ; umbilical cord; ; condyle; ; human fetus; ; fossa; ; dentate gyrus of hippocampal formation granule cell; ; blastocyst;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity; molecular function; protein binding;
Cellular component	extracellular exosome; cytoskeleton; keratin filament; intermediate filament; cytosol;
Biological process	keratinization; cornification; biological process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	374454
	406220
	ENSG00000189182
	ENSMUSG00000067594
	Q7Z794; Q0IIN1
	Q6IFZ6
	NM_175078
	NM_001003667
	NP_778253; NP_778253.2
	NP_001003667
	Wikidata
View/Edit Human	View/Edit Mouse

KRT77 encodes keratin 77, a member of the type II keratin family of intermediate filament proteins. Keratin 77 is also known as KRT1B, Type II cytoskeletal 1b, Type II keratin Kb39, and cytokeratin 1B. KRT77 is well-expressed by granular layer epidermal keratinocytes except for those that reside at acral surfaces.^[5] There is little to no expression of KRT77 in acral keratinocytes.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000189182 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067594 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16) e159762. doi:10.1172/jci.insight.159762. PMC 9462509. PMID 35900871.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000189182 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000067594 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[:0-5] 1 2 Merleev AA, Le ST, Alexanian C, Toussi A, Xie Y, Marusina AI, et al. (August 2022). "Biogeographic and disease-specific alterations in epidermal lipid composition and single-cell analysis of acral keratinocytes". JCI Insight. 7 (16) e159762. doi:10.1172/jci.insight.159762. PMC 9462509. PMID 35900871.

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References