Etifelmine
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Stimulant drug used to treat hypotension
Pharmaceutical compound
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| Formula | C17H19N |
| Molar mass | 237.346 g·mol−1 |
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Etifelmine (INN; also known as gilutensin) is a stimulant drug. It was used for the treatment of hypotension (low blood pressure).[1]
Synthesis
[edit]The base-catalyzed reaction between benzophenone (1) and butyronitrile (2) gives 2-[hydroxy(diphenyl)methyl]butanenitrile (3).[2][3] Catalytic hydrogenation reduces the nitrile group to a primary amine giving 1,1-diphenyl-2-ethyl-3-aminopropanol (4). The tertiary hydroxyl group is dehydrated by treatment with anhydrous hydrogen chloride gas, completing the synthesis of etifelmine (5).
See also
[edit]References
[edit]- ↑ Poepelmann H (August 1964). "The treatment of hypotensive circulatory disorders with gilutensin". Therapie der Gegenwart (in German). 103: 1007–12. PMID 14254672.
- ↑ Etifelmine, Thieme
- ↑ Dr Werner Heinrich & Dr Walter Heigel, DE 1122514 (1962 to Giulini Gmbh Geb).
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