UCD0168

UCD0168

Clinical data
Other names	UCD-0168
Drug class	Serotonin releasing agent
ATC code	None
Identifiers
IUPAC name 1-methyl-3-((1R,5S)-8-methyl-8-azabicyclo[3.2.1]oct-2-en-3-yl)-1H-indole
ChemSpider	133323943
Chemical and physical data
Formula	C17H20N2
Molar mass	252.361 g·mol−1
3D model (JSmol)	Interactive image
SMILES CN1C=C(C2=C[C@@H](CC3)N(C)[C@@H]3C2)C4=C1C=CC=C4
InChI InChI=1S/C17H20N2/c1-18-11-16(15-5-3-4-6-17(15)18)12-9-13-7-8-14(10-12)19(13)2/h3-6,9,11,13-14H,7-8,10H2,1-2H3/t13-,14+/m1/s1 Key:BBKRJDONOLKJBG-KGLIPLIRSA-N

UCD0168 is a serotonin releasing agent (SRA) of the tropane family related to the tryptamines. It is potent, selective, and shows full efficacy as an SRA in serotonin transporter (SERT)-transfected HEK293T cells. This includes selectivity for the SERT over the dopamine transporter (DAT) and norepinephrine transporter (NET). However, the drug also shows substantial interaction with the serotonin 5-HT₃ receptor and the sigma σ₁ and σ₂ receptor (92.5–95.1% binding inhibition, relative to 94.9% at the SERT). The chemical synthesis of UCD0168 has been described. Analogues of UCD0168 have been described, for instance UCD0820, which is a poorly selective SRA with partial releasing efficacy. UCD0168 was first described in the scientific literature by David E. Olson and colleagues at the University of California, Davis (UCD) in 2025.