Atypical chemokine receptor 4

ACKR4
Identifiers
Aliases	ACKR4, CC-CKR-11, CCBP2, CCR-11, CCR10, CCR11, CCRL1, CCX CKR, CCX-CKR, CKR-11, PPR1, VSHK1, atypical chemokine receptor 4
External IDs	OMIM: 606065; MGI: 2181676; GeneCards: ACKR4
Gene location (Human) Chr. Chromosome 3 (human) Band 3q22.1 Start 132,597,270 bp End 132,618,967 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F1 Start 103,961,356 bp End 104,004,132 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in duodenum ascending aorta gallbladder Descending thoracic aorta subcutaneous adipose tissue right coronary artery skin of leg Achilles tendon skin of abdomen pituitary gland Top expressed in lip morula choroid plexus of fourth ventricle body of femur umbilical cord esophagus calvaria thymus stroma of bone marrow zone of skin More reference expression data BioGPS n/a
Gene ontology Molecular function signal transducer activity chemokine binding scavenger receptor activity G protein-coupled receptor activity protein binding chemokine receptor activity C-C chemokine receptor activity C-C chemokine binding Cellular component recycling endosome plasma membrane membrane endosome integral component of membrane early endosome integral component of plasma membrane external side of plasma membrane Biological process receptor-mediated endocytosis signal transduction immune response chemotaxis G protein-coupled receptor signaling pathway chemokine-mediated signaling pathway positive regulation of cytosolic calcium ion concentration calcium-mediated signaling cell chemotaxis vesicle-mediated transport endocytosis Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51554 252837 Ensembl ENSG00000129048 ENSMUSG00000079355 UniProt Q9NPB9 Q924I3 RefSeq (mRNA) NM_178445 NM_016557 NM_145700 RefSeq (protein) NP_057641 NP_848540 NP_663746 Location (UCSC) Chr 3: 132.6 – 132.62 Mb Chr 9: 103.96 – 104 Mb PubMed search
Wikidata
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Atypical chemokine receptor 4 is a protein that in humans is encoded by the ACKR4 gene (previously CCRL1).

The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. Alternatively spliced transcript variants encoding the same protein have been described.

See also

• Duffy antigen system (ACKR1)
• Atypical chemokine receptor 2
• Atypical chemokine receptor 3
• Atypical chemokine receptor 5

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Bacon KB, Schall TJ, Dairaghi DJ (1998). "RANTES activation of phospholipase D in Jurkat T cells: requirement of GTP-binding proteins ARF and RhoA". J. Immunol. 160 (4): 1894–900. doi:10.4049/jimmunol.160.4.1894. PMID 9469451.
• Gosling J, Dairaghi DJ, Wang Y, et al. (2000). "Cutting edge: identification of a novel chemokine receptor that binds dendritic cell- and T cell-active chemokines including ELC, SLC, and TECK". J. Immunol. 164 (6): 2851–6. doi:10.4049/jimmunol.164.6.2851. PMID 10706668.
• Schweickart VL, Epp A, Raport CJ, Gray PW (2000). "CCR11 is a functional receptor for the monocyte chemoattractant protein family of chemokines". J. Biol. Chem. 275 (13): 9550–6. doi:10.1074/jbc.275.13.9550. PMID 10734104.
• Schweickart VL, Epp A, Raport CJ, Gray PW (2001). "CCR11 is a functional receptor for the monocyte chemoaattractant protein family of chemokines". The Journal of Biological Chemistry. 276 (1): 856. PMID 11134065.
• Townson JR, Nibbs RJ (2002). "Characterization of mouse CCX-CKR, a receptor for the lymphocyte-attracting chemokines TECK/mCCL25, SLC/mCCL21 and MIP-3beta/mCCL19: comparison to human CCX-CKR". Eur. J. Immunol. 32 (5): 1230–41. doi:10.1002/1521-4141(200205)32:5<1230::AID-IMMU1230>3.0.CO;2-L. PMID 11981810. S2CID 21911348.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Comerford I, Milasta S, Morrow V, et al. (2006). "The chemokine receptor CCX-CKR mediates effective scavenging of CCL19 in vitro". Eur. J. Immunol. 36 (7): 1904–16. doi:10.1002/eji.200535716. PMID 16791897. S2CID 31855788.

External links

• Human ACKR4 genome location and ACKR4 gene details page in the UCSC Genome Browser.
• Human CCR10 genome location and CCR10 gene details page in the UCSC Genome Browser.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.