CCL13

CCL13
Identifiers
Aliases	CCL13, CKb10, MCP-4, NCC-1, NCC1, SCYA13, SCYL1, C-C motif chemokine ligand 13
External IDs	OMIM: 601391; MGI: 98259; GeneCards: CCL13
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2RA4
Gene location (Human)
Chr.	Chromosome 17 (human)
End	34,358,610 bp
Gene location (Mouse)
Chr.	Chromosome 11 (mouse)
End	82,037,453 bp
RNA expression pattern
	Top expressed in
	gonad; ; mucosa of transverse colon; ; decidua; ; tibial nerve; ; epithelium of colon; ; tendon of biceps brachii; ; rectum; ; Achilles tendon; ; duodenum; ; right adrenal cortex;
	Top expressed in
	endothelial cell of lymphatic vessel; ; stroma of bone marrow; ; spermatid; ; embryo; ; cranial nervi; ; trigeminal nerve; ; ophthalmic nerve; ; interventricular septum; ; sciatic nerve; ; inner muscle layer;
	More reference expression data
	n/a
Gene ontology
Molecular function	cytokine activity; chemokine activity; CCR chemokine receptor binding; signaling receptor binding; protein binding;
Cellular component	extracellular region; extracellular space;
Biological process	monocyte chemotaxis; cell-cell signaling; eosinophil chemotaxis; chemotaxis; positive regulation of GTPase activity; cytoskeleton organization; immune response; positive regulation of ERK1 and ERK2 cascade; regulation of cell shape; signal transduction; inflammatory response; antimicrobial humoral immune response mediated by antimicrobial peptide; cellular calcium ion homeostasis; neutrophil chemotaxis; lymphocyte chemotaxis; chemokine-mediated signaling pathway; cellular response to interferon-gamma; cellular response to interleukin-1; cellular response to tumor necrosis factor; regulation of signaling receptor activity; G protein-coupled receptor signaling pathway; cell chemotaxis;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6357
	20296
	ENSG00000181374
	ENSMUSG00000035385
	Q99616
	P10148
	NM_005408
	NM_011333
	NP_005399
	NP_035463
	Wikidata
View/Edit Human	View/Edit Mouse

Chemokine (C-C motif) ligand 13 (CCL13) is a small cytokine belonging to the CC chemokine family. Its gene is located on human chromosome 17 within a large cluster of other CC chemokines.^[5]^[6] CCL13 induces chemotaxis in monocytes, eosinophils, T lymphocytes, and basophils by binding cell surface G-protein linked chemokine receptors such as CCR2, CCR3 and CCR5.^[7] Activity of this chemokine has been implicated in allergic reactions such as asthma.^[8] CCL13 can be induced by the inflammatory cytokines interleukin-1 and TNF-α.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000181374 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035385 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626
↑ Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.
↑ Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.
↑ Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000181374 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000035385 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Garcia-Zepeda EA, et al.. Human monocyte chemoattractant protein (MCP)-4 is a novel CC chemokine with activities on monocytes, eosinophils, and basophils induced in allergic and no allergic inflammation that signals through the CC chemokine receptors (CCR)-2 and -3. J Immunol. 1996;157:5613–5626

[6] Naruse et al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics. 1996, 34(2):236-40.

[7] Blanpain et al., CCR5 binds multiple CC-chemokines: MCP-3 acts as a natural antagonist. Blood. 1999, 94:1899-905.

[8] Lamkhioued et al., Monocyte chemoattractant protein (MCP)-4 expression in the airways of patients with asthma. Induction in epithelial cells and mononuclear cells by proinflammatory cytokines. Am J Respir Crit Care Med. 2000, 162:723-32.

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References