CCL14

CCL14
Identifiers
Aliases	CCL14, CC-1, CC-3, CKB1, HCC-1, HCC-1(1-74), HCC-1/HCC-3, HCC-3, MCIF, NCC-2, NCC2, SCYA14, SCYL2, SY14, C-C motif chemokine ligand 14
External IDs	OMIM: 601392; GeneCards: CCL14
Available structures
PDB	Human UniProt search: PDBe RCSB
List of PDB id codes
	2Q8R, 2Q8T
Gene location (Human)
Chr.	Chromosome 17 (human)
End	35,987,004 bp
RNA expression pattern
	Top expressed in
	spleen; ; subcutaneous adipose tissue; ; left uterine tube; ; lactiferous gland; ; gastric mucosa; ; canal of the cervix; ; body of uterus; ; myometrium; ; smooth muscle tissue; ; olfactory zone of nasal mucosa;
	n/a
	More reference expression data
	n/a
Gene ontology
Molecular function	chemokine activity; cytokine activity; CCR chemokine receptor binding;
Cellular component	extracellular region; extracellular space;
Biological process	chemokine-mediated signaling pathway; lymphocyte chemotaxis; cellular response to tumor necrosis factor; G protein-coupled receptor signaling pathway; positive regulation of GTPase activity; inflammatory response; cellular calcium ion homeostasis; cellular response to interleukin-1; monocyte chemotaxis; neutrophil chemotaxis; positive regulation of cell population proliferation; positive regulation of ERK1 and ERK2 cascade; immune response; cellular response to interferon-gamma; regulation of signaling receptor activity; positive regulation of inflammatory response;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6358
	n/a
	ENSG00000277236; ENSG00000276409
	n/a
	Q16627
	n/a
	NM_032963; NM_004166; NM_032962
	n/a
	NP_116738; NP_116739
	n/a
	Wikidata
View/Edit Human

Chemokine (C-C motif) ligand 14 (CCL14) is a small cytokine belonging to the CC chemokine family. It is also commonly known as HCC-1. It is produced as a protein precursor that is processed to generate a mature active protein containing 74 amino acids that and is 46% identical in amino acid composition to CCL3 and CCL4. This chemokine is expressed in various tissues including spleen, bone marrow, liver, muscle, and gut.^[3] CCL14 activates monocytes, but does not induce their chemotaxis. Human CCL14 is located on chromosome 17 within a cluster of other chemokines belonging to the CC family.^[4]

References

1 2 3 ENSG00000276409 GRCh38: Ensembl release 89: ENSG00000277236, ENSG00000276409 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.
↑ Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.

This article on a gene on human chromosome 17 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 ENSG00000276409 GRCh38: Ensembl release 89: ENSG00000277236, ENSG00000276409 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[3] Schulz-Knappe et al., HCC-1, a novel chemokine from human plasma. J. Exp. Med., 1996, 183: 295-299.

[4] Naruseet al., A YAC contig of the human CC chemokine genes clustered on chromosome 17q11.2. Genomics, 1996, 34: 236-240.

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References