RTF1

RTF1
Identifiers
Aliases	RTF1, GTL7, KIAA0252, RTF1 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 611633; MGI: 1309480; GeneCards: RTF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2BZE, 2DB9, 3U1U, 4L1P, 4L1U
Gene location (Human) Chr. Chromosome 15 (human) Band 15q15.1 Start 41,408,408 bp End 41,483,563 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 E5 Start 119,675,068 bp End 119,735,407 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence Skeletal muscle tissue of rectus abdominis palpebral conjunctiva epithelium of colon ventricular zone bone marrow cell cerebellar hemisphere Skeletal muscle tissue of biceps brachii body of tongue monocyte Top expressed in tail of embryo zygote genital tubercle hand yolk sac superior cervical ganglion foot interventricular septum primitive streak fossa More reference expression data BioGPS n/a
Gene ontology Molecular function protein binding single-stranded DNA binding DNA binding RNA polymerase II C-terminal domain phosphoserine binding RNA binding Cellular component nucleolus nucleus Cdc73/Paf1 complex nucleoplasm Biological process blastocyst growth histone modification regulation of transcription, DNA-templated positive regulation of transcription elongation from RNA polymerase II promoter histone H3-K4 trimethylation positive regulation of histone H3-K4 methylation transcription, DNA-templated Wnt signaling pathway positive regulation of transcription by RNA polymerase II negative regulation of transcription by RNA polymerase II stem cell population maintenance endodermal cell fate commitment transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter protein ubiquitination Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 23168 76246 Ensembl ENSG00000137815 ENSMUSG00000027304 UniProt Q92541 A2AQ19 RefSeq (mRNA) NM_015138 NM_030112 RefSeq (protein) NP_055953 NP_084388 Location (UCSC) Chr 15: 41.41 – 41.48 Mb Chr 2: 119.68 – 119.74 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Rtf1, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae) is a protein that in humans is encoded by the RTF1 gene. As its name suggests, this protein is part of the Paf1/RNA polymerase II complex, a multi-subunit complex involved in regulating DNA to RNA transcription by RNA polymerase II.

This locus may represent a gene involved in regulation of transcription elongation and chromatin remodeling, based on studies of similar proteins in other organisms. The encoded protein may bind single-stranded DNA.

See also

• RTF2

Further reading

• Rozenblatt-Rosen O, Hughes CM, Nannepaga SJ, Shanmugam KS, Copeland TD, Guszczynski T, et al. (January 2005). "The parafibromin tumor suppressor protein is part of a human Paf1 complex". Molecular and Cellular Biology. 25 (2): 612–620. doi:10.1128/MCB.25.2.612-620.2005. PMC 543415. PMID 15632063.
• Warner MH, Roinick KL, Arndt KM (September 2007). "Rtf1 is a multifunctional component of the Paf1 complex that regulates gene expression by directing cotranscriptional histone modification". Molecular and Cellular Biology. 27 (17): 6103–6115. doi:10.1128/MCB.00772-07. PMC 1952162. PMID 17576814.
• de Jong RN, Truffault V, Diercks T, Ab E, Daniels MA, Kaptein R, et al. (January 2008). "Structure and DNA binding of the human Rtf1 Plus3 domain". Structure. 16 (1): 149–159. doi:10.1016/j.str.2007.10.018. hdl:1874/33204. PMID 18184592. S2CID 38494347.
• Nordick K, Hoffman MG, Betz JL, Jaehning JA (July 2008). "Direct interactions between the Paf1 complex and a cleavage and polyadenylation factor are revealed by dissociation of Paf1 from RNA polymerase II". Eukaryotic Cell. 7 (7): 1158–1167. doi:10.1128/EC.00434-07. PMC 2446681. PMID 18469135.
• Lango Allen H, Estrada K, Lettre G, Berndt SI, Weedon MN, Rivadeneira F, et al. (October 2010). "Hundreds of variants clustered in genomic loci and biological pathways affect human height". Nature. 467 (7317): 832–838. Bibcode:2010Natur.467..832L. doi:10.1038/nature09410. PMC 2955183. PMID 20881960.
• Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, et al. (October 1996). "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain". DNA Research. 3 (5): 321–329, 341–329. doi:10.1093/dnares/3.5.321. PMID 9039502.