Replication termination factor 2

"RTF2" redirects here. For the Glock model, see Glock § Second-generation models. For the Australian army task force, see 1st Battalion, Royal Australian Regiment § 2nd Reconstruction Task Force.

RTF2
Identifiers
Aliases	RTF2, C20orf43, CDAO5, HSPC164, SHUJUN-3, replication termination factor 2 domain containing 1, replication termination factor 2, RTFDC1
External IDs	MGI: 1913654; GeneCards: RTF2
Gene location (Human) Chr. Chromosome 20 (human) Band 20q13.31 Start 56,468,585 bp End 56,519,449 bp
Gene location (Mouse) Chr. Chromosome 2 (mouse) Band 2|2 H3 Start 172,282,476 bp End 172,311,828 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Achilles tendon monocyte popliteal artery gastrocnemius muscle ganglionic eminence prefrontal cortex caudate nucleus ascending aorta left coronary artery right coronary artery Top expressed in spermatid granulocyte lip spermatocyte dentate gyrus of hippocampal formation granule cell left lobe of liver neural tube thymus lumbar spinal ganglion ventricular zone More reference expression data BioGPS More reference expression data
Gene ontology Molecular function molecular function DNA binding protein binding Cellular component nucleus cellular component replication fork chromosome Biological process mitotic DNA replication termination site-specific DNA replication termination at RTS1 barrier biological process cellular response to hydroxyurea regulation of DNA stability Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51507 66404 Ensembl ENSG00000022277 ENSMUSG00000027502 UniProt Q9BY42 Q99K95 RefSeq (mRNA) NM_001283035 NM_001283036 NM_001283037 NM_016407 NM_025542 NM_175297 RefSeq (protein) NP_001269964 NP_001269965 NP_001269966 NP_057491 NP_079818 Location (UCSC) Chr 20: 56.47 – 56.52 Mb Chr 2: 172.28 – 172.31 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Replication termination factor 2 is a protein that in humans is encoded by the RTF2 gene. The RTF2 protein is a DNA binding protein that research suggests plays a role in DNA damage response and repair, but its precise functions remains uncertain.

See also

• RTF1

External links

• Human RTFDC1 genome location and RTFDC1 gene details page in the UCSC Genome Browser.

Further reading

• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
• Hu RM, Han ZG, Song HD, et al. (2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
• Zhang QH, Ye M, Wu XY, et al. (2001). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC 310934. PMID 11042152.
• Deloukas P, Matthews LH, Ashurst J, et al. (2002). "The DNA sequence and comparative analysis of human chromosome 20". Nature. 414 (6866): 865–71. Bibcode:2001Natur.414..865D. doi:10.1038/414865a. PMID 11780052.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Andersen JS, Lam YW, Leung AK, et al. (2005). "Nucleolar proteome dynamics". Nature. 433 (7021): 77–83. Bibcode:2005Natur.433...77A. doi:10.1038/nature03207. PMID 15635413. S2CID 4344740.