PTPN23

PTPN23
Identifiers
Aliases	PTPN23, HD-PTP, HDPTP, PTP-TD14, protein tyrosine phosphatase, non-receptor type 23, protein tyrosine phosphatase non-receptor type 23, NEDBASS
External IDs	OMIM: 606584; MGI: 2144837; HomoloGene: 135706; GeneCards: PTPN23; OMA:PTPN23 - orthologs
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3RAU, 5CRV, 5CRU
Enzyme activity EC # BRENDA ExPASy KEGG MetaCyc 3.1.3.48 ↗ ↗ ↗ ↗
Gene location (Human) Chr. Chromosome 3 (human) Band 3p21.31 Start 47,381,011 bp End 47,413,435 bp
Gene location (Mouse) Chr. Chromosome 9 (mouse) Band 9|9 F2 Start 110,214,150 bp End 110,237,281 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in sural nerve pituitary gland skin of arm anterior pituitary right hemisphere of cerebellum right lobe of thyroid gland stromal cell of endometrium left lobe of thyroid gland gastrocnemius muscle canal of the cervix Top expressed in internal carotid artery ventricular zone external carotid artery yolk sac granulocyte neural layer of retina superior frontal gyrus tail of embryo primary visual cortex genital tubercle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function phosphoprotein phosphatase activity phosphatase activity protein binding protein tyrosine phosphatase activity protein kinase binding hydrolase activity Cellular component cytoplasm ciliary basal body endosome cell projection cilium nucleoplasm early endosome extracellular exosome cytoskeleton cytoplasmic vesicle nucleus nuclear body cytosol Biological process positive regulation of homophilic cell adhesion cilium assembly regulation of cell migration protein dephosphorylation positive regulation of adherens junction organization cell projection organization protein transport positive regulation of early endosome to late endosome transport ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway negative regulation of epithelial cell migration dephosphorylation peptidyl-tyrosine dephosphorylation early endosome to late endosome transport positive regulation of Wnt protein secretion transport endocytic recycling cellular response to cytokine stimulus Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25930 104831 Ensembl ENSG00000076201 ENSMUSG00000036057 UniProt Q9H3S7 Q6PB44 RefSeq (mRNA) NM_001304482 NM_015466 NM_001081043 RefSeq (protein) NP_001291411 NP_056281 NP_001074512 Location (UCSC) Chr 3: 47.38 – 47.41 Mb Chr 9: 110.21 – 110.24 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein phosphatase non-receptor type 23 is an enzyme that in humans is encoded by the PTPN23 gene.

Further reading

• Nakajima D, Okazaki N, Yamakawa H, et al. (2003). "Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones". DNA Res. 9 (3): 99–106. doi:10.1093/dnares/9.3.99. PMID 12168954.
• Nagase T, Kikuno R, Ishikawa K, et al. (2000). "Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (2): 143–50. doi:10.1093/dnares/7.2.143. PMID 10819331.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
• Mariotti M, Castiglioni S, Maier JA (2006). "Expression analysis and modulation by HIV-Tat of the tyrosine phosphatase HD-PTP". J. Cell. Biochem. 98 (2): 301–8. doi:10.1002/jcb.20770. PMID 16408268. S2CID 9546573.
• Mariotti M, Castiglioni S, Beguinot L, Maier JA (2006). "The tyrosine phosphatase HD-PTP is regulated by FGF-2 through proteasome degradation" (PDF). Front. Biosci. 11: 2138–43. doi:10.2741/1956. hdl:2434/18210. PMID 16720300. S2CID 39603646.
• Castiglioni S, Maier JA, Mariotti M (2007). "The tyrosine phosphatase HD-PTP: A novel player in endothelial migration". Biochem. Biophys. Res. Commun. 364 (3): 534–9. doi:10.1016/j.bbrc.2007.10.022. PMID 17959146.

External links

• Overview of all the structural information available in the PDB for UniProt: Q9H3S7 (Human Tyrosine-protein phosphatase non-receptor type 23 (PTPN23)) at the PDBe-KB.