PAF1

PAF1
Identifiers
Aliases	PAF1, F23149_1, PD2, PAF1 homolog, Paf1/RNA polymerase II complex component
External IDs	OMIM: 610506; MGI: 1923988; GeneCards: PAF1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4M6T
Gene location (Human) Chr. Chromosome 19 (human) Band 19q13.2 Start 39,385,629 bp End 39,391,154 bp
Gene location (Mouse) Chr. Chromosome 7 (mouse) Band 7|7 A3 Start 28,092,376 bp End 28,098,813 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in tendon of biceps brachii sural nerve left testis right testis internal globus pallidus gastric mucosa C1 segment anterior pituitary ventricular zone left ovary Top expressed in otic vesicle saccule otic placode neural layer of retina ascending aorta aortic valve supraoptic nucleus yolk sac interventricular septum granulocyte More reference expression data BioGPS n/a
Gene ontology Molecular function RNA polymerase II complex binding chromatin binding protein binding Cellular component cytoplasm membrane cell junction Cdc73/Paf1 complex nucleus nucleoplasm Biological process histone monoubiquitination regulation of transcription, DNA-templated positive regulation of histone methylation positive regulation of mRNA 3'-end processing histone modification negative regulation of transcription by RNA polymerase II Wnt signaling pathway transcription, DNA-templated stem cell population maintenance mRNA polyadenylation endodermal cell fate commitment protein localization to nucleus histone H2B ubiquitination cellular response to lipopolysaccharide negative regulation of myeloid cell differentiation positive regulation of transcription elongation from RNA polymerase II promoter positive regulation of transcription by RNA polymerase II transcription by RNA polymerase II transcription elongation from RNA polymerase II promoter protein ubiquitination positive regulation of cell cycle G1/S phase transition Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 54623 54624 Ensembl ENSG00000006712 ENSMUSG00000003437 UniProt Q8N7H5 Q8K2T8 RefSeq (mRNA) NM_001256826 NM_019088 NM_019458 RefSeq (protein) NP_001243755 NP_061961 NP_062331 Location (UCSC) Chr 19: 39.39 – 39.39 Mb Chr 7: 28.09 – 28.1 Mb PubMed search
Wikidata
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RNA polymerase II-associated factor 1 homolog (PAF1), also called PD2, is a protein that in humans is encoded by the PAF1 gene. This protein is a component of the polymerase associated factor (PAF1) complex, which is involved in the transcription of DNA into mRNA through interaction with RNA Polymerase II. PAF1 is necessary for maintaining the complex's integrity.

PAF1 complex

The polymerase associated factor complex (PAF1C) is a multi-protein subunit complex found in humans and many other organisms (though much of the early research was in budding yeast). This complex functions as a regulator of all stages of RNA Polymerase II-based transcription. For example, the PAF1 Complex promotes transcription elongation through interaction with elongation factors like the DSIF and FACT complexes.

In humans, it is composed of 6 protein subunits: PAF1, CDC73, LEO1, CTR9, RTF1 and SKIC8, which notably differs from yeast by the additional of SKIC8 Both PAF1 and CDC73 seem necessary for maintaining complex integrity, and yeast without Paf1 or Cdc73 suffer severe growth defects.