Magnolysin
| Magnolysin | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 3.4.24.62 | ||||||||
| CAS no. | 162875-09-4 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| |||||||||
Magnolysin (EC 3.4.24.62, bovine neurosecretory granule protease cleaving pro-oxytocin/neurophysin, pro-oxytocin/neurophysin convertase, prooxyphysin proteinase, pro-oxytocin convertase) is an enzyme.[1][2][3][4][5] This enzyme catalyses the following chemical reaction
- Hydrolysis of polypeptides with Arg or Lys in P1 and P2, e.g. to hydrolyse pro-oxytocin at -Lys-Arg-Ala-Val-.
This endopeptidase is present in bovine pituitary neurosecretory granules.
References
[edit]- ↑ Clamagirand C, Creminon C, Fahy C, Boussetta H, Cohen P (September 1987). "Partial purification and functional properties of an endoprotease from bovine neurosecretory granules cleaving proocytocin/neurophysin peptides at the basic amino acid doublet". Biochemistry. 26 (19): 6018–23. doi:10.1021/bi00393a011. PMID 2825769.
- ↑ Créminon C, Rholam M, Boussetta H, Marrakchi N, Cohen P (May 1988). "Synthetic peptide substrates as models to study a pro-ocytocin/neurophysin converting enzyme". Journal of Chromatography. 440: 439–48. doi:10.1016/s0021-9673(00)94547-3. PMID 3042797.
- ↑ Brakch N, Boussetta H, Rholam M, Cohen P (September 1989). "Processing endoprotease recognizes a structural feature at the cleavage site of peptide prohormones. The pro-ocytocin/neurophysin model". The Journal of Biological Chemistry. 264 (27): 15912–6. doi:10.1016/S0021-9258(18)71565-2. PMID 2674120.
- ↑ Plevrakis I, Clamagirand C, Créminon C, Brakch N, Rholam M, Cohen P (March 1989). "Proocytocin/neurophysin convertase from bovine neurohypophysis and corpus luteum secretory granules: complete purification, structure-function relationships, and competitive inhibitor". Biochemistry. 28 (6): 2705–10. doi:10.1021/bi00432a051. PMID 2659078.
- ↑ Guillou MD, Camier M, Clamagirand C (August 1994). "Evidence for the presence of pro-oxytocin/neurophysin-converting enzyme in the human ovary". The Journal of Endocrinology. 142 (2): 345–52. doi:10.1677/joe.0.1420345. PMID 7931007.
External links
[edit]- Magnolysin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
