ADAM28

ADAM28
Identifiers
Aliases	ADAM28, ADAM 28, ADAM23, MDC-L, MDC-Lm, MDC-Ls, MDCL, eMDC II, eMDCII, ADAM metallopeptidase domain 28
External IDs	OMIM: 606188; MGI: 105988; HomoloGene: 40705; GeneCards: ADAM28; OMA:ADAM28 - orthologs
Gene location (Human)
Chr.	Chromosome 8 (human)
End	24,359,014 bp
Gene location (Mouse)
Chr.	Chromosome 14 (mouse)
End	68,893,291 bp
RNA expression pattern
	Top expressed in
	corpus epididymis; ; nasal epithelium; ; olfactory zone of nasal mucosa; ; gallbladder; ; pancreatic ductal cell; ; right uterine tube; ; epithelium of nasopharynx; ; mucosa of paranasal sinus; ; bronchial epithelial cell; ; appendix;
	Top expressed in
	superior surface of tongue; ; gallbladder; ; Ileal epithelium; ; nasal epithelium; ; olfactory epithelium; ; transitional epithelium of urinary bladder; ; corneal stroma; ; plantaris muscle; ; extensor digitorum longus muscle; ; interventricular septum;
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	peptidase activity; metalloendopeptidase activity; hydrolase activity; metallopeptidase activity; metal ion binding;
Cellular component	integral component of membrane; extracellular region; membrane; mitochondrion; plasma membrane;
Biological process	spermatogenesis; proteolysis;
	Sources:Amigo / QuickGO
Orthologs
	10863
	13522
	ENSG00000042980
	ENSMUSG00000014725
	Q9UKQ2
	Q9JLN6
	NM_001304351; NM_014265; NM_021777
	NM_001048175; NM_010082; NM_176991; NM_183366
	NP_001291280; NP_055080; NP_068547
	NP_001041640; NP_034212; NP_899222
	Wikidata
View/Edit Human	View/Edit Mouse

Disintegrin and metalloproteinase domain-containing protein 28 is an enzyme that in humans is encoded by the ADAM28 gene.^[5]

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. Alternative splicing results in two transcript variants. The shorter version encodes a secreted isoform, while the longer version encodes a transmembrane isoform.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000042980 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014725 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 "Entrez Gene: ADAM28 ADAM metallopeptidase domain 28".

External links

The MEROPS online database for peptidases and their inhibitors: M12.224^{[dead link]}
Human ADAM28 genome location and ADAM28 gene details page in the UCSC Genome Browser.

This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000042980 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014725 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 "Entrez Gene: ADAM28 ADAM metallopeptidase domain 28".

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[2]

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[4]

[5]

v t e Proteases: metalloendopeptidases (EC 3.4.24)
ADAM proteins	Alpha secretases ADAM9 ADAM10 ADAM17 ADAM19 ADAM2 ADAM7 ADAM8 ADAM11 ADAM12 ADAM15 ADAM18 ADAM22 ADAM23 ADAM28 ADAM33 ADAMTS1 ADAMTS2 ADAMTS3 ADAMTS4 ADAMTS5 ADAMTS8 ADAMTS9 ADAMTS10 ADAMTS12 ADAMTS13
Matrix metalloproteinases	Collagenases MMP1 MMP8 Gelatinases MMP2 MMP9 MMP3 MMP7 MMP10 MMP11 MMP12 MMP13 MMP14 MMP15 MMP16 MMP17 MMP19 MMP20 MMP21 MMP23A MMP23B MMP24 MMP25 MMP26 MMP27 MMP28
Other	Neprilysin Procollagen peptidase Thermolysin Pappalysin-1 Bone morphogenetic protein 1 Lysostaphin Insulin-degrading enzyme ZMPSTE24

v t e Enzymes
Activity	Active site Binding site Catalytic triad Oxyanion hole Enzyme promiscuity Diffusion-limited enzyme Cofactor Enzyme catalysis
Regulation	Allosteric regulation Cooperativity Enzyme inhibitor Enzyme activator
Classification	EC number Enzyme superfamily Enzyme family List of enzymes
Kinetics	Enzyme kinetics Eadie–Hofstee diagram Hanes–Woolf plot Lineweaver–Burk plot Michaelis–Menten kinetics
Types	EC1 Oxidoreductases (list) EC2 Transferases (list) EC3 Hydrolases (list) EC4 Lyases (list) EC5 Isomerases (list) EC6 Ligases (list) EC7 Translocases (list)

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ADAM28

References

Further reading

External links