GPR25

GPR25
Identifiers
Aliases	GPR25, G protein-coupled receptor 25
External IDs	OMIM: 602174; MGI: 2686146; GeneCards: GPR25
Gene location (Human)
Chr.	Chromosome 1 (human)
End	200,874,178 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	136,188,611 bp
RNA expression pattern
	Top expressed in
	gonad; ; granulocyte; ; blood; ; appendix; ; right uterine tube; ; body of stomach; ; spleen; ; fundus; ; upper lobe of left lung; ; face;
	Top expressed in
	prefrontal cortex; ; nucleus accumbens; ; visual cortex; ; subiculum; ; hippocampus proper; ; primary visual cortex; ; temporal lobe; ; piriform cortex; ; cerebellum; ; stria vascularis;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity;
Cellular component	integral component of membrane; plasma membrane; integral component of plasma membrane; membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	2848
	383563
	ENSG00000170128
	ENSMUSG00000052759
	O00155
	P0C5I1
	NM_005298
	NM_001101516
	NP_005289
	NP_001094986
	Wikidata
View/Edit Human	View/Edit Mouse

C-X-C chemokine receptor GPR25 is a protein that in humans is encoded by the GPR25 gene.^[5]^[6]

Structure

It is a member of the G protein-coupled receptor (GPCR) family and is well conserved in vertebrate evolution containing a canonical DRYLAVV motif in the third transmembrane sequence. It has a conserved negatively charged N-terminal extracellular peptide comprising a DY candidate sulfation site that is characteristic of many leukocyte chemoattractant receptors for positively charged polypeptides of the chemokine family.^[7]

Tissue distribution

GPR25 expression is largely restricted to lymphocytes and natural killer (NK) cells.^[7]

Function

It has been identified as the receptor for the chemokine-like protein CXCL17.^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170128 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052759 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Jung BP, Nguyen T, Kolakowski LF Jr, Lynch KR, Heng HH, George SR, et al. (Feb 1997). "Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1". Biochemical and Biophysical Research Communications. 230 (1): 69–72. doi:10.1006/bbrc.1996.5828. PMID 9020062.
↑ "Entrez Gene: GPR25 G protein-coupled receptor 25".
1 2 3 Ocón B, Xiang M, Bi Y, Tan S, Brulois K, Ayesha A, et al. (21 November 2024). "A lymphocyte chemoaffinity axis for lung, non-intestinal mucosae and CNS". Nature. 635 (8039): 736–745. Bibcode:2024Natur.635..736O. doi:10.1038/s41586-024-08043-2. PMC 11887596. PMID 39293486.

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GPR25

Structure

Tissue distribution

Function

References

Further reading