GPR85

GPR85
Identifiers
Aliases	GPR85, SREB, SREB2, G protein-coupled receptor 85
External IDs	OMIM: 605188; MGI: 1927851; HomoloGene: 10355; GeneCards: GPR85; OMA:GPR85 - orthologs
Gene location (Human)
Chr.	Chromosome 7 (human)
End	113,087,778 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	13,839,941 bp
RNA expression pattern
	Top expressed in
	endothelial cell; ; caudate nucleus; ; primary visual cortex; ; putamen; ; dorsolateral prefrontal cortex; ; ganglionic eminence; ; prefrontal cortex; ; lateral nuclear group of thalamus; ; nucleus accumbens; ; Brodmann area 23;
	Top expressed in
	barrel cortex; ; Rostral migratory stream; ; Region I of hippocampus proper; ; piriform cortex; ; ventromedial nucleus; ; substantia nigra; ; temporal lobe; ; facial motor nucleus; ; lobe of cerebellum; ; habenula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	G protein-coupled receptor activity; protein binding; signal transducer activity;
Cellular component	integral component of membrane; endoplasmic reticulum; membrane; plasma membrane;
Biological process	G protein-coupled receptor signaling pathway; signal transduction;
	Sources:Amigo / QuickGO
Orthologs
	54329
	64450
	ENSG00000164604
	ENSMUSG00000048216
	P60893
	P60894
	NM_001146265; NM_001146266; NM_001146267; NM_018970
	NM_145066; NM_001330666; NM_001330667
	NP_001139737; NP_001139738; NP_001139739; NP_061843
	NP_001317595; NP_001317596; NP_659503
	Wikidata
View/Edit Human	View/Edit Mouse

Probable G-protein coupled receptor 85 is a protein that in humans is encoded by the GPR85 gene.^[5]^[6]^[7]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000164604 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048216 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hellebrand S, Schaller HC, Wittenberger T (September 2000). "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (1–2): 269–272. doi:10.1016/s0167-4781(00)00182-2. PMID 10978537.
↑ Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, et al. (June 2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system". Biochemical and Biophysical Research Communications. 272 (2): 576–582. doi:10.1006/bbrc.2000.2829. PMID 10833454.
↑ "Entrez Gene: GPR85 G protein-coupled receptor 85".

The Sanger Centre, The Washington University Genome Sequencing Center (November 1998). "Toward a complete human genome sequence". Genome Research. 8 (11): 1097–1108. doi:10.1101/gr.8.11.1097. PMID 9847074.
Hartley JL, Temple GF, Brasch MA (November 2000). "DNA cloning using in vitro site-specific recombination". Genome Research. 10 (11): 1788–1795. doi:10.1101/gr.143000. PMC 310948. PMID 11076863.
Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, et al. (March 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Research. 11 (3): 422–435. doi:10.1101/gr.GR1547R. PMC 311072. PMID 11230166.
Simpson JC, Wellenreuther R, Poustka A, Pepperkok R, Wiemann S (September 2000). "Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing". EMBO Reports. 1 (3): 287–292. doi:10.1093/embo-reports/kvd058. PMC 1083732. PMID 11256614.
Jeon J, Kim C, Sun W, Chung H, Park SH, Kim H (November 2002). "Cloning and localization of rgpr85 encoding rat G-protein-coupled receptor". Biochemical and Biophysical Research Communications. 298 (4): 613–618. doi:10.1016/S0006-291X(02)02515-9. PMID 12408996.
Wiemann S, Arlt D, Huber W, Wellenreuther R, Schleeger S, Mehrle A, et al. (October 2004). "From ORFeome to biology: a functional genomics pipeline". Genome Research. 14 (10B): 2136–2144. doi:10.1101/gr.2576704. PMC 528930. PMID 15489336.
Matsumoto M, Beltaifa S, Weickert CS, Herman MM, Hyde TM, Saunders RC, et al. (July 2005). "A conserved mRNA expression profile of SREB2 (GPR85) in adult human, monkey, and rat forebrain". Brain Research. Molecular Brain Research. 138 (1): 58–69. doi:10.1016/j.molbrainres.2005.04.002. PMID 15893849.
Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, et al. (January 2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Research. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129. PMID 16344560.
Mehrle A, Rosenfelder H, Schupp I, del Val C, Arlt D, Hahne F, et al. (January 2006). "The LIFEdb database in 2006". Nucleic Acids Research. 34 (Database issue): D415–D418. doi:10.1093/nar/gkj139. PMC 1347501. PMID 16381901.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000164604 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000048216 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10978537-5] Hellebrand S, Schaller HC, Wittenberger T (September 2000). "The brain-specific G-protein coupled receptor GPR85 with identical protein sequence in man and mouse maps to human chromosome 7q31". Biochimica et Biophysica Acta (BBA) - Gene Structure and Expression. 1493 (1–2): 269–272. doi:10.1016/s0167-4781(00)00182-2. PMID 10978537.

[pmid10833454-6] Matsumoto M, Saito T, Takasaki J, Kamohara M, Sugimoto T, Kobayashi M, et al. (June 2000). "An evolutionarily conserved G-protein coupled receptor family, SREB, expressed in the central nervous system". Biochemical and Biophysical Research Communications. 272 (2): 576–582. doi:10.1006/bbrc.2000.2829. PMID 10833454.

[entrez-7] "Entrez Gene: GPR85 G protein-coupled receptor 85".

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GPR85

See also

References

Further reading