Dextrin dextranase
| dextrin dextranase | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Identifiers | |||||||||
| EC no. | 2.4.1.2 | ||||||||
| CAS no. | 9032-13-7 | ||||||||
| Databases | |||||||||
| BRENDA | enzyme data | ||||||||
| ExPASy | NiceZyme view | ||||||||
| KEGG | enzyme entry | ||||||||
| MetaCyc | metabolic pathway | ||||||||
| Rhea | reactions | ||||||||
| PDB structures | RCSB PDB PDBe PDBsum | ||||||||
| Gene Ontology | AmiGO / QuickGO | ||||||||
| |||||||||
In enzymology, a dextrin dextranase (EC 2.4.1.2) is an enzyme that catalyzes the chemical reaction
- (1,4-alpha-D-glucosyl)n + (1,6-alpha-D-glucosyl)m (1,4-alpha-D-glucosyl)n-1 + (1,6-alpha-D-glucosyl)m+1
Thus, the two substrates of this enzyme are (1,4-alpha-D-glucosyl)n and (1,6-alpha-D-glucosyl)m, whereas its two products are (1,4-alpha-D-glucosyl)n-1 and (1,6-alpha-D-glucosyl)m+1.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is 1,4-alpha-D-glucan:1,6-alpha-D-glucan 6-alpha-D-glucosyltransferase. Other names in common use include dextrin 6-glucosyltransferase, and dextran dextrinase. If the enzyme predominantly catalyzes the synthesis of dextran from dextrin, the name "dextran dextrinase" is considered more appropriate.
In 2025, the three-dimensional structure of dextran dextrinase from Gluconobacter oxydans was reported. The enzyme shows a strong structural similarity to glucoamylases and glucodextranases, which hydrolyze dextrin and dextran. However, a spatial shift of about 1.5 Å in the catalytic residues enables dextran dextrinase to catalyze transglucosylation reactions.
References
[edit]- Hehre EJ (1951). "Enzymic Synthesis of Polysaccharides: A Biological type of Polymerization". Advances in Enzymology and Related Areas of Molecular Biology. Advances in Enzymology and Related Subjects of Biochemistry. Vol. 11. pp. 297–337. doi:10.1002/9780470122563.ch6. ISBN 9780470122563. PMID 24540594.
{{cite book}}: ISBN / Date incompatibility (help) - Hehre EJ, Hamilton DM (1949). "Bacterial conversion of dextrin into a polysaccharide with the serological properties of dextran". Proc. Soc. Exp. Biol. Med. 71 (3): 336–339. doi:10.3181/00379727-71-17183. PMID 18136472.
- Hehre EJ, Hamilton DM (1953). "The biological synthesis of dextran from dextrins". J. Biol. Chem. 192: 161–174. doi:10.1016/S0021-9258(18)55917-2. PMID 14917661.
- Tagami T, Saburi W, Sadahiro J, Kumagai Y, Lang W, Matsugaki N, Okuyama M, Mori H, and Kimura A (2025). "Structural basis of transglucosylation in dextran dextrinase, a homolog of anomer-inverting GH15 glucoside hydrolases." J. Biol. Chem. 301, 110541. doi: 10.1016/j.jbc.2025.110541. PMID 40749827
 | This EC 2.4 enzyme-related article is a stub. You can help Wikipedia by adding missing information. |