FUT5

FUT5
Identifiers
Aliases	FUT5, FUC-TV, fucosyltransferase 5
External IDs	OMIM: 136835; HomoloGene: 134030; GeneCards: FUT5; OMA:FUT5 - orthologs
Enzyme activity
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,870,540 bp
RNA expression pattern
	Top expressed in
	bone marrow; ; right lobe of liver; ; anterior pituitary; ; skin of leg; ; testicle; ; islet of Langerhans; ; left testis; ; right testis; ; head; ; skin of abdomen;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity; alpha-(1->3)-fucosyltransferase activity; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity; glycosyltransferase activity; fucosyltransferase activity;
Cellular component	integral component of membrane; Golgi cisterna membrane; Golgi apparatus; membrane; Golgi membrane;
Biological process	protein glycosylation; L-fucose catabolic process; fucosylation; ceramide metabolic process; carbohydrate metabolic process;
	Sources:Amigo / QuickGO
Orthologs
	2527
	n/a
	ENSG00000130383
	n/a
	Q11128
	n/a
	NM_002034
	n/a
	NP_002025
	n/a
	Wikidata
View/Edit Human

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT5 gene.^[3]^[4]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000130383 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Weston BW, Nair RP, Larsen RD, Lowe JB (February 1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities". The Journal of Biological Chemistry. 267 (6): 4152–60. doi:10.1016/S0021-9258(19)50641-X. PMID 1740457.
↑ "Entrez Gene: FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)".

Chiu PC, Chung MK, Koistinen R, Koistinen H, Seppala M, Ho PC, Ng EH, Lee KF, Yeung WS (January 2007). "Glycodelin-A interacts with fucosyltransferase on human sperm plasma membrane to inhibit spermatozoa-zona pellucida binding". Journal of Cell Science. 120 (Pt 1): 33–44. doi:10.1242/jcs.03258. hdl:10722/45488. PMID 17148576.
Inaba Y, Ohyama C, Kato T, Satoh M, Saito H, Hagisawa S, Takahashi T, Endoh M, Fukuda MN, Arai Y, Fukuda M (December 2003). "Gene transfer of alpha1,3-fucosyltransferase increases tumor growth of the PC-3 human prostate cancer cell line through enhanced adhesion to prostatic stromal cells". International Journal of Cancer. 107 (6): 949–57. doi:10.1002/ijc.11513. PMID 14601054. S2CID 7078688.
Roos C, Kolmer M, Mattila P, Renkonen R (February 2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". The Journal of Biological Chemistry. 277 (5): 3168–75. doi:10.1074/jbc.M107927200. PMID 11698403.
Nishihara S, Iwasaki H, Kaneko M, Tawada A, Ito M, Narimatsu H (December 1999). "Alpha1,3-fucosyltransferase 9 (FUT9; Fuc-TIX) preferentially fucosylates the distal GlcNAc residue of polylactosamine chain while the other four alpha1,3FUT members preferentially fucosylate the inner GlcNAc residue". FEBS Letters. 462 (3): 289–94. doi:10.1016/S0014-5793(99)01549-5. PMID 10622713. S2CID 37842289.
McCurley RS, Recinos A, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (March 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.
Cameron HS, Szczepaniak D, Weston BW (August 1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms". The Journal of Biological Chemistry. 270 (34): 20112–22. doi:10.1074/jbc.270.34.20112. PMID 7650030.
Weston BW, Smith PL, Kelly RJ, Lowe JB (December 1992). "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes". The Journal of Biological Chemistry. 267 (34): 24575–84. doi:10.1016/S0021-9258(18)35803-4. PMID 1339443.

This article on a gene on human chromosome 19 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000130383 – Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1740457-3] Weston BW, Nair RP, Larsen RD, Lowe JB (February 1992). "Isolation of a novel human alpha (1,3)fucosyltransferase gene and molecular comparison to the human Lewis blood group alpha (1,3/1,4)fucosyltransferase gene. Syntenic, homologous, nonallelic genes encoding enzymes with distinct acceptor substrate specificities". The Journal of Biological Chemistry. 267 (6): 4152–60. doi:10.1016/S0021-9258(19)50641-X. PMID 1740457.

[entrez-4] "Entrez Gene: FUT5 fucosyltransferase 5 (alpha (1,3) fucosyltransferase)".

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This page was redesigned at the edge.

FUT5

References

Further reading