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Cycloproscaline

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Cycloproscaline
Clinical data
Other namesCP; 4-Cyclopropoxy-3,5-dimethoxyphenethylamine; 4-cPrO-3,5-DMPEA
Routes of
administration		Oral[1][2]
Drug classSerotonin receptor modulator; Serotonin 5-HT2A receptor agonist; Serotonergic psychedelic; Hallucinogen
ATC code
  • None
Pharmacokinetic data
Duration of action≥6 hours[1][2]
Identifiers
  • 2-(4-cyclopropyloxy-3,5-dimethoxyphenyl)ethanamine
CAS Number
PubChem CID
ChemSpider
Chemical and physical data
FormulaC13H19NO3
Molar mass237.299 g·mol−1
3D model (JSmol)
  • COC1=CC(=CC(=C1OC2CC2)OC)CCN
  • InChI=1S/C13H19NO3/c1-15-11-7-9(5-6-14)8-12(16-2)13(11)17-10-3-4-10/h7-8,10H,3-6,14H2,1-2H3
  • Key:VRTSLAVKWTZKIT-UHFFFAOYSA-N

Cycloproscaline (CP), also known as 4-cyclopropoxy-3,5-dimethoxyphenethylamine (4-cPrO-3,5-DMPEA), is a psychedelic drug of the phenethylamine and scaline families related to mescaline.[1][2] It is the homologue of mescaline in which the 4-methoxy group has been replaced with a 4-cyclopropoxy group.[1][2] The drug has a dose of 60 mg or more orally and a duration of 6 hours or more, but has not been fully evaluated.[1][2] It is a low-potency full agonist of the serotonin 5-HT2A receptor and also interacts with other serotonin receptors such as the serotonin 5-HT1A and 5-HT2C receptors.[2] The drug's chemical synthesis has been described.[1] Cycloproscaline was first described in the scientific literature by Daniel Trachsel and colleagues in 2013.[1] Its pharmacology was studied in greater detail in 2021.[2] The drug is not a controlled substance in Canada as of 2025.[3]

See also

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References

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  1. 1 2 3 4 5 6 7 Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine: von der Struktur zur Funktion [Phenethylamines: From Structure to Function]. Nachtschatten-Science (in German) (1 ed.). Solothurn: Nachtschatten-Verlag. pp. 706, 713–716. ISBN 978-3-03788-700-4. OCLC 858805226.
  2. 1 2 3 4 5 6 7 Kolaczynska KE, Luethi D, Trachsel D, Hoener MC, Liechti ME (2021). "Receptor Interaction Profiles of 4-Alkoxy-3,5-Dimethoxy-Phenethylamines (Mescaline Derivatives) and Related Amphetamines". Frontiers in Pharmacology. 12 794254. doi:10.3389/fphar.2021.794254. PMC 8865417. PMID 35222010.
  3. ↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.
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