Chromosomal passenger complex
The chromosomal passenger complex (CPC) is a protein complex composed of Aurora B kinase, Survivin, Borealin and inner centromere protein.[1]
The CPC is mainly located at the inner centromere during mitotic cell divisions, through interactions with nucleosomes.[1][2] It plays multiple regulatory roles during cell division including sister chromatid cohesion, mediating attachments between kinetochores and microtubules, and the spindle assembly checkpoint.[3]
References
[edit]- 1 2 Gireesh, Anjitha; Abad, Maria Alba; Nozawa, Ryu-Suke; Sotelo-Parrilla, Paula; Dury, Léa C; Likhodeeva, Mariia; Wear, Martin; Spanos, Christos; Peralta, Cristina Cardenal; Rappsilber, Juri; Hopfner, Karl-Peter; Wilson, Marcus D; Vanderlinden, Willem; Hirota, Toru; Jeyaprakash, A Arockia (17 November 2025). "Nucleosome interaction of the CPC secures centromeric chromatin integrity and chromosome segregation fidelity". The EMBO Journal. 44 (22). doi:10.1038/s44318-025-00594-y.
- ↑ Ruza, Reinis R; Chung, Chyi Wei; Gold, Danny B H; Serena, Michela; Roberts, Emile; Gruneberg, Ulrike; Barr, Francis A (9 September 2025). "A pivot-tether model for nucleosome recognition by the chromosomal passenger complex". EMBO Reports. 26 (17). doi:10.1038/s44319-025-00523-4.
- ↑ Carmena, Mar; Wheelock, Michael; Funabiki, Hironori; Earnshaw, William C. (December 2012). "The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis". Nature Reviews Molecular Cell Biology. 13 (12): 789–803. doi:10.1038/nrm3474.
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