Bremazocine

Bremazocine
Clinical data
Routes of; administration	Oral
ATC code	none;
Identifiers
	IUPAC name 6-ethyl- 3-[(1-hydroxycyclopropyl)methyl]- 11,11-dimethyl- 1,2,3,4,5,6-hexahydro- 2,6-methano- 3-benzazocin-8- ol; or; 2-(1-hydroxy- cyclopropylmethyl)- 5-ethyl- 9,9-dimethyl- 2'-hydroxy- 6,7-benzomorphan;
CAS Number	83829-76-9 ;
PubChem CID	1223;
IUPHAR/BPS	1603;
ChemSpider	1186;
UNII	ISF76M2DBE;
ChEMBL	ChEMBL1797687;
CompTox Dashboard (EPA)	DTXSID50868536 ;
Chemical and physical data
Formula	C20H29NO2
Molar mass	315.457 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES OC1(CC1)CN4[C@@H]3Cc2c(cc(O)cc2)[C@@](C3(C)C)(CC4)CC;

Bremazocine is a κ-opioid receptor agonist related to pentazocine. It has potent and long-lasting analgesic and diuretic effects.^[1] It has 200 times the activity of morphine, but appears to have no addictive properties and does not depress breathing.^[2] The crystal structure of bremazocine was determined in 1984 ^[3]

References

↑ Dortch-Carnes J, Potter DE (2005). "Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties". CNS Drug Reviews. 11 (2): 195–212. doi:10.1111/j.1527-3458.2005.tb00270.x. PMC 6741727. PMID 16007240.
↑ Patrick G (2013). An Introduction to Medicinal Chemistry (5th expanded ed.). Oxford University Press. p. 641. ISBN 978-0199697397.
↑ Verlinde CL, Blaton NM, De Ranter CJ, Peeters OM (1984). "5-Ethyl-2'-hydroxy-2-[(1-hydroxycyclopropyl) methyl]-9, 9-dimethyl-6, 7-benzomorphan hydrochloride (bremazocine), C20H29NO2. HCl". Acta Crystallogr. C. 40 (10): 1759–1761. Bibcode:1984AcCrC..40.1759V. doi:10.1107/S0108270184009434.

This analgesic-related article is a stub. You can help Wikipedia by adding missing information.

[pmid16007240-1] Dortch-Carnes J, Potter DE (2005). "Bremazocine: a kappa-opioid agonist with potent analgesic and other pharmacologic properties". CNS Drug Reviews. 11 (2): 195–212. doi:10.1111/j.1527-3458.2005.tb00270.x. PMC 6741727. PMID 16007240.

[2] Patrick G (2013). An Introduction to Medicinal Chemistry (5th expanded ed.). Oxford University Press. p. 641. ISBN 978-0199697397.

[3] Verlinde CL, Blaton NM, De Ranter CJ, Peeters OM (1984). "5-Ethyl-2'-hydroxy-2-[(1-hydroxycyclopropyl) methyl]-9, 9-dimethyl-6, 7-benzomorphan hydrochloride (bremazocine), C20H29NO2. HCl". Acta Crystallogr. C. 40 (10): 1759–1761. Bibcode:1984AcCrC..40.1759V. doi:10.1107/S0108270184009434.

[1]

[2]

[3]

v t e Hallucinogens
Psychedelics (5-HT_2A agonists)	Tryptamines (e.g., DMT, psilocin, psilocybin, bufotenin, 5-MeO-DMT, AMT) Phenethylamines (e.g., mescaline, 2C-B, DOM, MDA, TMA, 2C-B-FLY, 25I-NBOMe) Lysergamides (e.g., LSD, ergine, isoergine) Others (e.g., efavirenz, glaucine, IHCH-7113, MK-212, quipazine, RH-34) For a full list of serotonergic psychedelics, see the navbox here and the list here instead.
Dissociatives (NMDA antagonists)	Arylcyclohexylamines (e.g., ketamine (K), phencyclidine (PCP), methoxetamine (MXE), tiletamine) Adamantanes (e.g., memantine, amantadine) Diarylethylamines (e.g., diphenidine, ephenidine, methoxphenidine) Morphinans (e.g., dextromethorphan (DXM), dextrorphan (DXO)) Inhalants (e.g., nitrous oxide (N₂O), xenon (Xe)) Others (e.g., alkyl nitrites/poppers, aptiganel, dexoxadrol, dizocilpine (MK-801), etoxadrol, selfotel) For a full list of dissociatives, see the navbox here instead.
Deliriants (mACh antagonists)	Tropanes: Atropine Hyoscyamine Scopolamine (hyoscine) Antihistamines: Brompheniramine Chloropyramine Chlorphenamine (chlorpheniramine) Clemastine Cyclizine Cyproheptadine Dimenhydrinate Diphenhydramine Doxylamine Meclizine Mepyramine Pheniramine Phenyltoloxamine Promethazine Tripelennamine Triprolidine Others: Benactyzine Benapryzine (benaprizine) Benzatropine (benztropine) Biperiden BZ (QNB) CAR-226,086 CAR-301,060 CAR-302,196 CAR-302,282 CAR-302,668 CS-27349 Cycrimine Dicycloverine Ditran (JB-329) EA-3167 EA-3443 EA-3580 EA-3834 Flavoxate JB-318 JB-336 Orphenadrine Oxybutynin Procyclidine Tolterodine Trihexyphenidyl Tropicamide Tropine benzilate WIN-2299
KOR agonists	Salvinoids (terpenoids): 2-EMSB 2-MMSB RB-64 (22-thiocyanatosalvinorin A) Salvinorin A Benzomorphans: Alazocine Bremazocine Cyclazocine Ketazocine Metazocine MR-2034 Pentazocine Phenazocine Morphinans: Butorphanol Cyclorphan Cyprenorphine Diprenorphine Heroin Levallorphan Levomethorphan Levorphanol Morphine Nalbuphine Nalmefene Nalorphine Oxilorphan Proxorphan Racemethorphan Racemorphan Xorphanol Arylacetamides: Enadoline LPK-26 Niravoline Spiradoline U-50488 U-69593 Others: HZ-2 Tifluadom
GABA_A agonists	Isoxazoles: Gaboxadol (THIP) Ibotenic acid (Amanita muscaria) Muscimol (Amanita muscaria) Indirect GABA_A receptor agonists: GABA_A receptor positive allosteric modulators (nonbenzodiazepines/Z-drugs) (e.g., eszopiclone, zaleplon, zolpidem, zopiclone) GABA reuptake inhibitors (e.g., CI-966)
Oneirogens (unknown mech.)	Harmala alkaloids/β-carbolines (e.g., harmine, harmaline, tetrahydroharmine, 6-methoxyharmalan, 6-MeO-THH) (found in Peganum harmala, Banisteriopsis caapi) Iboga alkaloids/azepinoindoles (e.g., ibogaine, noribogaine) (found in Tabernanthe iboga)
Cannabinoids (CB₁ agonists)	Phytocannabinoids (e.g., Δ⁹-THC (dronabinol), CBN, Δ⁸-THC) Synthetic cannabinoids (e.g., nabilone, JWH-018, JWH-073, HU-210) For a full list of cannabinoids, see the navbox here and the list here instead.
Others	Aminochromes (e.g., adrenochrome, adrenolutin) Carbogen Glaucine Hallucinogenic bolete mushrooms (e.g., Lanmaoa asiatica) Hallucinogenic fish (ichthyoallyeinotoxism) Icelandic hallucinogenic lichen ("rock soup") Jenkem Kambo (sapo; Phyllomedusa bicolor skin secretions) Kykeon (Eleusinian Mysteries) Mad honey (Rhododendron; grayanotoxins) Nutmeg (e.g., myristicin, elemicin) Sinicuichi (e.g., cryogenine) Soma (haoma) Hallucinogen combinations (e.g., ayahuasca, teotlaqualli) Others (e.g., insect hallucinogens)
See also: Psychedelics Dissociatives Entactogens Stimulants Depressants List of hallucinogens

This page was redesigned at the edge.

See also

References