Benzomorphan
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| Names | |
|---|---|
| IUPAC name
6,7-Benzomorphan | |
Other names
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| Identifiers | |
3D model (JSmol) |
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| ChemSpider | |
PubChem CID |
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| UNII | |
CompTox Dashboard (EPA) |
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| Properties | |
| C12H15N | |
| Molar mass | 173.259 g·mol−1 |
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
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Benzomorphan is a chemical compound that is the base for a series of drugs which variably act on the sigma receptors and κ-opioid receptors, including the following compounds:
- 5,9-DEHB
- 8-CAC
- Alazocine
- Anazocine
- Bremazocine
- Butinazocine
- Carbazocine
- Cogazocine
- Cyclazocine
- Dezocine
- Eptazocine (Homobenzomorphan)
- Etazocine
- Ethylketocyclazocine
- Fluorophen
- Gemazocine
- Gpa-1657 [14578-59-7][1]
- GPA 1658 HCl salt: [26862-29-3][2]
- GPA-208
- GPA-3154 Fb: [35758-34-0] HCl salt: [35758-32-8]
- Ibazocine
- ID-1229 [56390-16-0][3][4][5]
- LP-1[6]
- Ketazocine
- Metazocine
- Moxazocine
- Mr2266 [56649-76-4]
- MR-2034, MR-2033-CL [57236-85-8]
- Pentazocine
- Phenazocine
- Quadazocine
- Thiazocine[citation needed]
- Tonazocine
- Volazocine
- Zenazocine
Some of these agents are used as analgesics, including pentazocine, phenazocine, dezocine, and eptazocine.[7][8]
See also
[edit]References
[edit]- ↑ Yokoyama, Naokata; Almaula, Prabodh I.; Block, Fred B.; Granat, Frank R.; Gottfried, Norman; Hill, Ronald T.; McMahon, Elihu H.; Munch, Walter F.; Rachlin, Howard (1979). "Syntheses, analgetic activity and physical dependence capacity of 5-phenyl-6,7-benzomorphan derivatives". Journal of Medicinal Chemistry. 22 (5): 537–553. doi:10.1021/jm00191a016. PMID 37335.
- ↑ Yokoyama, Naokata; Block, Fred B.; Clarke, Frank H. (1970). "1,2,3,4,5,6-Hexahydro-6-phenyl-2,6-methano-3-benzazocines. II". Journal of Medicinal Chemistry. 13 (3): 488–492. doi:10.1021/jm00297a034.
- ↑ Castañer, J.; Paton, D. M. (1978). "ID-1229". Drugs of the Future. 3 (4): 298. doi:10.1358/dof.1978.003.04.65215. ISSN 0377-8282. Retrieved 21 October 2025.
- ↑ Yamamoto H, Saito C, Inaba S, Inukai T, Kobayashi K (May 1975). "The synthesis and pharmacology of a new analgesic, ID-1229". Arzneimittel-Forschung. 25 (5): 795–801. doi:10.1002/chin.197534266. PMID 1242327.
- ↑ Yamamoto, H, Saito, C, Inaba, S, Inukai, T, Kobayashi, K, Fukumaru, T, Koga, Y, Homma, T, Asami, Y (26 August 1975). "ChemInform Abstract: THE SYNTHESIS AND PHARMACOLOGY OF A NEW ANALGESIC, ID-1229". Chemischer Informationsdienst. 6 (34) chin.197534266. doi:10.1002/chin.197534266. ISSN 0009-2975. PMID 1242327. Retrieved 21 October 2025.
- ↑ Parenti, Carmela; Turnaturi, Rita; Aricò, Giuseppina; Marrazzo, Agostino; Prezzavento, Orazio; Ronsisvalle, Simone; Scoto, Giovanna M.; Ronsisvalle, Giuseppe; Pasquinucci, Lorella (2012). "Antinociceptive profile of LP1, a non-peptide multitarget opioid ligand". Life Sciences. 90 (25–26): 957–961. doi:10.1016/j.lfs.2012.04.041. PMID 22580287.
- ↑ Kar, Ashutosh (2005). Medicinal Chemistry. New Age International. ISBN 978-81-224-1565-0.
- ↑ Cittern PA, Kapoor VK, Parfitt RT (October 1986). "Preparation and analgesic activity of (−)-11 alpha-substituted 1,2,3,4,5,6-hexahydro-6 alpha,7-(methyleneoxy)-2,6-methano-3-benzazocines". Journal of Medicinal Chemistry. 29 (10): 1929–33. doi:10.1021/jm00160a022. PMID 2876100.
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