2C-T-29

2C-T-29
Clinical data
Other names	2C-T-PARGY; 2C-T-PROPARGYL; 2,5-Dimethoxy-4-propargylthiophenethylamine; 4-Propargylthio-2,5-dimethoxyphenethylamine
Identifiers
	IUPAC name 2-(2,5-dimethoxy-4-prop-2-ynylsulfanylphenyl)ethanamine;
PubChem CID	169149320;
Chemical and physical data
Formula	C13H17NO2S
Molar mass	251.34 g·mol−1
3D model (JSmol)	Interactive image;
	SMILES COC1=CC(=C(C=C1CCN)OC)SCC#C;
	InChI InChI=1S/C13H17NO2S/c1-4-7-17-13-9-11(15-2)10(5-6-14)8-12(13)16-3/h1,8-9H,5-7,14H2,2-3H3; Key:BWTBPZDUQOTNBE-UHFFFAOYSA-N;

2C-T-29, also known as 2C-T-PARGY or 2C-T-PROPARGYL or as 4-propargylthio-2,5-dimethoxyphenethylamine, is a designer drug from the substituted phenethylamine family, which was first synthesised by Josh Hartsel and colleagues in 2024. It is a potent agonist at the serotonin receptor 5-HT_2A in vitro, with a binding affinity (K_i) of 1.3 nM and an EC₅₀ of 0.67 nM, acting as a full agonist.^[1] While the closely related propylthio compound 2C-T-7 and the allylthio derivative 2C-T-16 are both known to be potent psychedelic drugs in humans, the propargylthio analogue 2C-T-29 is not known to have been tested in humans or other animals.^[2] It is a controlled substance in Canada under phenethylamine blanket-ban language.^[3]

References

↑ Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A (April 2024). "Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT₂ Receptor Agonist". Journal of Medicinal Chemistry. 67 (8): 6144–6188. doi:10.1021/acs.jmedchem.3c01961. PMID 38593423.
↑ Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. pp. 792–795. ISBN 978-3-03788-700-4.
↑ "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.

External links

2C-T-29 - Isomer Design

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[1] Varty GB, Canal CE, Mueller TA, Hartsel JA, Tyagi R, Avery K, Morgan ME, Reichelt AC, Pathare P, Stang E, Palfreyman MG, Nivorozhkin A (April 2024). "Synthesis and Structure-Activity Relationships of 2,5-Dimethoxy-4-Substituted Phenethylamines and the Discovery of CYB210010: A Potent, Orally Bioavailable and Long-Acting Serotonin 5-HT₂ Receptor Agonist". Journal of Medicinal Chemistry. 67 (8): 6144–6188. doi:10.1021/acs.jmedchem.3c01961. PMID 38593423.

[2] Trachsel D, Lehmann D, Enzensperger C (2013). Phenethylamine Von der Struktur zur Funktion. Nachtschatten Verlag AG. pp. 792–795. ISBN 978-3-03788-700-4.

[CDSA-3] "Controlled Drugs and Substances Act". Department of Justice Canada. Retrieved 19 January 2026.

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2C-T-29

See also

References

External links