KRT75

KRT75
Identifiers
Aliases	KRT75, K6HF, KB18, PFB, keratin 75, CK-75, hK6hf, K75
External IDs	OMIM: 609025; MGI: 1923500; GeneCards: KRT75
Gene location (Human)
Chr.	Chromosome 12 (human)
End	52,434,371 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	101,482,339 bp
RNA expression pattern
	Top expressed in
	hair follicle; ; skin of abdomen; ; skin of limb; ; skin of leg; ; nipple; ; mucosa of esophagus; ; pharynx; ; cervix; ; vagina; ; tonsil;
	Top expressed in
	hair follicle; ; lip; ; conjunctival fornix; ; skin of back; ; urethra; ; molar; ; skin of abdomen; ; embryo; ; skin of external ear; ; cornea;
	More reference expression data
	n/a
Gene ontology
Molecular function	structural molecule activity;
Cellular component	keratin filament; extracellular exosome; intracellular anatomical structure; intermediate filament; cytosol;
Biological process	hematopoietic progenitor cell differentiation; keratinization; cornification;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	9119
	109052
	ENSG00000170454
	ENSMUSG00000022986
	O95678
	Q8BGZ7
	NM_004693
	NM_133357
	NP_004684
	NP_579935
	Wikidata
View/Edit Human	View/Edit Mouse

Keratin, type II cytoskeletal 75 is a protein that in humans is encoded by the KRT75 gene. It is a type of keratin involved in hair shaft structure in mice.^[5] In chickens, mutations in KRT75 cause animals to have frizzled feathers.^[6]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000170454 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022986 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Liu Y, Snedecor ER, Zhang X, Xu Y, Huang L, Jones EC, Zhang L, Clark RA, Roop DR, Qin C, Chen J (January 2016). "Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75". The Journal of Investigative Dermatology. 136 (1): 45–51. doi:10.1038/JID.2015.375. PMC 4764097. PMID 26763422.
↑ Ng CS, Wu P, Foley J, Foley A, McDonald ML, Juan WT, Huang CJ, Lai YT, Lo WS, Chen CF, Leal SM, Zhang H, Widelitz RB, Patel PI, Li WH, Chuong CM (2012). "The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis". PLOS Genetics. 8 (7) e1002748. doi:10.1371/journal.pgen.1002748. PMC 3400578. PMID 22829773.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000170454 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022986 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] Liu Y, Snedecor ER, Zhang X, Xu Y, Huang L, Jones EC, Zhang L, Clark RA, Roop DR, Qin C, Chen J (January 2016). "Correction of Hair Shaft Defects through Allele-Specific Silencing of Mutant Krt75". The Journal of Investigative Dermatology. 136 (1): 45–51. doi:10.1038/JID.2015.375. PMC 4764097. PMID 26763422.

[6] Ng CS, Wu P, Foley J, Foley A, McDonald ML, Juan WT, Huang CJ, Lai YT, Lo WS, Chen CF, Leal SM, Zhang H, Widelitz RB, Patel PI, Li WH, Chuong CM (2012). "The chicken frizzle feather is due to an α-keratin (KRT75) mutation that causes a defective rachis". PLOS Genetics. 8 (7) e1002748. doi:10.1371/journal.pgen.1002748. PMC 3400578. PMID 22829773.

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References