KIF7

KIF7
Identifiers
Aliases	KIF7, ACLS, HLS2, JBTS12, UNQ340, AGBK, kinesin family member 7
External IDs	OMIM: 611254; MGI: 1098239; HomoloGene: 72555; GeneCards: KIF7; OMA:KIF7 - orthologs
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	2XT3, 4A14
Gene location (Human)
Chr.	Chromosome 15 (human)
End	89,655,467 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	79,365,468 bp
RNA expression pattern
	Top expressed in
	gonad; ; ascending aorta; ; right ovary; ; ventricular zone; ; gastric mucosa; ; stromal cell of endometrium; ; left ovary; ; Descending thoracic aorta; ; left uterine tube; ; testicle;
	Top expressed in
	hand; ; molar; ; foot; ; ventricular zone; ; maxillary prominence; ; endocardial cushion; ; mandibular prominence; ; medullary collecting duct; ; Gonadal ridge; ; genital tubercle;
	More reference expression data
	n/a
Gene ontology
Molecular function	microtubule binding; microtubule motor activity; nucleotide binding; protein binding; ATP binding; plus-end-directed microtubule motor activity; ATPase activity;
Cellular component	cell projection; ciliary tip; cilium; kinesin complex; ciliary basal body; cytoplasm; cytoskeleton; microtubule;
Biological process	microtubule-based movement; negative regulation of smoothened signaling pathway; positive regulation of smoothened signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	374654
	16576
	ENSG00000166813
	ENSMUSG00000050382
	Q2M1P5
	B7ZNG0
	NM_198525
	NM_001291222; NM_010626
	NP_940927
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Kinesin family member 7 (KIF7), also known as kinesin-4, is a human protein encoded by the gene KIF7. It is part of the kinesin family of motor proteins.

Function

KIF7 depolymerises the growing plus-end of microtubules, and is involved in regulating Hedgehog signalling.^[5]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166813 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050382 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV (July 2014). "The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment". Nature Cell Biology. 16 (7): 663–672. doi:10.1038/ncb2988. PMC 4085576. PMID 24952464.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166813 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000050382 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[5] He M, Subramanian R, Bangs F, Omelchenko T, Liem KF, Kapoor TM, Anderson KV (July 2014). "The kinesin-4 protein Kif7 regulates mammalian Hedgehog signalling by organizing the cilium tip compartment". Nature Cell Biology. 16 (7): 663–672. doi:10.1038/ncb2988. PMC 4085576. PMID 24952464.

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Function

References