STYXL1

STYXL1
Identifiers
Aliases	STYXL1, DUSP24, MK-STYX, MKSTYX, serine/threonine/tyrosine interacting-like 1, serine/threonine/tyrosine interacting like 1
External IDs	OMIM: 616695; MGI: 1923821; GeneCards: STYXL1
Gene location (Human) Chr. Chromosome 7 (human) Band 7q11.23 Start 75,996,338 bp End 76,048,004 bp
Gene location (Mouse) Chr. Chromosome 5 (mouse) Band 5|5 G2 Start 135,776,074 bp End 135,807,239 bp
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right uterine tube mucosa of transverse colon islet of Langerhans granulocyte monocyte body of pancreas rectum olfactory zone of nasal mucosa nasal epithelium epithelium of bronchus Top expressed in spermatid seminiferous tubule spermatocyte granulocyte embryo blastocyst lumbar spinal ganglion morula right kidney medial ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function hydrolase activity protein tyrosine/serine/threonine phosphatase activity phosphoprotein phosphatase activity pseudophosphatase activity protein phosphatase inhibitor activity protein binding protein phosphatase binding Cellular component mitochondrion mitochondrial matrix Biological process intracellular signal transduction protein dephosphorylation dephosphorylation positive regulation of neuron projection development negative regulation of phosphoprotein phosphatase activity regulation of intrinsic apoptotic signaling pathway positive regulation of intrinsic apoptotic signaling pathway negative regulation of stress granule assembly Sources:Amigo / QuickGO
Orthologs Databases NCBI: entry; OMA: entry Species Human Mouse Entrez 51657 76571 Ensembl ENSG00000127952 ENSMUSG00000019178 UniProt Q9Y6J8 n/a RefSeq (mRNA) NM_016086 NM_001317785 NM_001317786 NM_001317787 NM_001317788 NM_001317789 NM_001289554 NM_001289555 NM_001289556 NM_001289557 NM_029659 RefSeq (protein) NP_001304714 NP_001304715 NP_001304716 NP_001304717 NP_001304718 NP_057170 n/a Location (UCSC) Chr 7: 76 – 76.05 Mb Chr 5: 135.78 – 135.81 Mb PubMed search
Wikidata
View/Edit Human View/Edit Mouse

Serine/threonine/tyrosine-interacting-like protein 1 is a protein, encoded in humans by the STYXL1 gene (previously DUSP24). It is a phosphatase-like protein that is no longer able to act as an enzyme. Instead, it binds to proteins like G3BP1 and PTPMT1 and inhibits certain activities.

Further reading

• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948. PMID 17353931.
• Cheng J, Kapranov P, Drenkow J, et al. (2005). "Transcriptional maps of 10 human chromosomes at 5-nucleotide resolution". Science. 308 (5725): 1149–54. Bibcode:2005Sci...308.1149C. doi:10.1126/science.1108625. PMID 15790807. S2CID 13047538.
• Barrios-Rodiles M, Brown KR, Ozdamar B, et al. (2005). "High-throughput mapping of a dynamic signaling network in mammalian cells". Science. 307 (5715): 1621–5. Bibcode:2005Sci...307.1621B. doi:10.1126/science.1105776. PMID 15761153. S2CID 39457788.
• Siligan C, Ban J, Bachmaier R, et al. (2005). "EWS-FLI1 target genes recovered from Ewing's sarcoma chromatin". Oncogene. 24 (15): 2512–24. doi:10.1038/sj.onc.1208455. PMID 15735734.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
• Hillier LW, Fulton RS, Fulton LA, et al. (2003). "The DNA sequence of human chromosome 7". Nature. 424 (6945): 157–64. Bibcode:2003Natur.424..157H. doi:10.1038/nature01782. PMID 12853948.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.