SBF1

SBF1
Identifiers
Aliases	SBF1, CMT4B3, DENND7A, MTMR5, SET binding factor 1
External IDs	OMIM: 603560; MGI: 1925230; GeneCards: SBF1
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1V5U
Gene location (Human)
Chr.	Chromosome 22 (human)
End	50,483,923 bp
Gene location (Mouse)
Chr.	Chromosome 15 (mouse)
End	89,199,514 bp
RNA expression pattern
	Top expressed in
	left testis; ; right testis; ; right lobe of thyroid gland; ; left lobe of thyroid gland; ; right hemisphere of cerebellum; ; right frontal lobe; ; cingulate gyrus; ; C1 segment; ; anterior cingulate cortex; ; amygdala;
	Top expressed in
	dentate gyrus of hippocampal formation granule cell; ; neural layer of retina; ; spermatocyte; ; superior frontal gyrus; ; ventricular zone; ; primary visual cortex; ; thymus; ; granulocyte; ; lip; ; esophagus;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	phosphatase regulator activity; protein tyrosine/serine/threonine phosphatase activity; guanyl-nucleotide exchange factor activity; phosphatase activity;
Cellular component	integral component of membrane; nucleus; cytosol; endoplasmic reticulum membrane; cytoplasm; nuclear body; perinuclear region of cytoplasm;
Biological process	regulation of GTPase activity; protein dephosphorylation; spermatogenesis; phosphatidylinositol biosynthetic process;
	Sources:Amigo / QuickGO
Orthologs
Databases	NCBI: entry; OMA: entry
	6305
	77980
	ENSG00000100241
	ENSMUSG00000036529
	O95248
	Q6ZPE2
	NM_002972; NM_001365819
	NM_001081030; NM_001170561; NM_030019
	NP_002963; NP_001352748
	NP_001074499; NP_001164032
	Wikidata
View/Edit Human	View/Edit Mouse

Myotubularin-related protein 5 is a protein that in humans is encoded by the SBF1 gene.^[5]^[6]^[7]

Interactions

SBF1 has been shown to interact with MTMR2^[8] and SUV39H1.^[9]

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000100241 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036529 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML (April 1998). "Association of SET domain and myotubularin-related proteins modulates growth control". Nat. Genet. 18 (4): 331–7. doi:10.1038/ng0498-331. PMID 9537414. S2CID 25209204.
↑ Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (December 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.
↑ "Entrez Gene: SBF1 SET binding factor 1".
↑ Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (April 2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. Bibcode:2003PNAS..100.4492K. doi:10.1073/pnas.0431052100. PMC 153583. PMID 12668758.
↑ Firestein R, Cui X, Huie P, Cleary ML (July 2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC 85941. PMID 10848615.

External links

Overview of all the structural information available in the PDB for UniProt: Q6ZPE2 (Mouse Myotubularin-related protein 5) at the PDBe-KB.

This article on a gene on human chromosome 22 is a stub. You can help Wikipedia by adding missing information.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000100241 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000036529 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9537414-5] Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML (April 1998). "Association of SET domain and myotubularin-related proteins modulates growth control". Nat. Genet. 18 (4): 331–7. doi:10.1038/ng0498-331. PMID 9537414. S2CID 25209204.

[pmid9736772-6] Laporte J, Blondeau F, Buj-Bello A, Tentler D, Kretz C, Dahl N, Mandel JL (December 1998). "Characterization of the myotubularin dual specificity phosphatase gene family from yeast to human". Hum. Mol. Genet. 7 (11): 1703–12. doi:10.1093/hmg/7.11.1703. PMID 9736772.

[entrez-7] "Entrez Gene: SBF1 SET binding factor 1".

[pmid12668758-8] Kim SA, Vacratsis PO, Firestein R, Cleary ML, Dixon JE (April 2003). "Regulation of myotubularin-related (MTMR)2 phosphatidylinositol phosphatase by MTMR5, a catalytically inactive phosphatase". Proc. Natl. Acad. Sci. U.S.A. 100 (8): 4492–7. Bibcode:2003PNAS..100.4492K. doi:10.1073/pnas.0431052100. PMC 153583. PMID 12668758.

[pmid10848615-9] Firestein R, Cui X, Huie P, Cleary ML (July 2000). "Set domain-dependent regulation of transcriptional silencing and growth control by SUV39H1, a mammalian ortholog of Drosophila Su(var)3-9". Mol. Cell. Biol. 20 (13): 4900–9. doi:10.1128/MCB.20.13.4900-4909.2000. PMC 85941. PMID 10848615.

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SBF1

Interactions

References

Further reading

External links